Metal-Free [2+2+2] Cycloaddition of Ynamides with Nitriles to Construct 2,4-Diaminopyridines

被引：42
|
作者：
Zhang, Jingyi
Zhang, Qingshuang
Xia, Biao
Wu, Jie
Wang, Xiao-Na [1 ]
Chang, Junbiao [1 ]
机构：
[1] Zhengzhou Univ, Sch Pharmaceut Sci, Collaborat Innovat Ctr New Drug Res & Safety Eval, Henan Prov, Zhengzhou 450001, Henan, Peoples R China
来源：
ORGANIC LETTERS | 2016年 / 18卷 / 14期
基金：
中国国家自然科学基金; 中国博士后科学基金;
关键词：
N BOND-CLEAVAGE; IRON-CATALYZED CYCLOADDITION; ROOM-TEMPERATURE; PYRIDINES; DIYNES; CYCLOTRIMERIZATION; CYANAMIDES; YNAMINES; ALKYNES; HETEROCYCLES;
D O I：
10.1021/acs.orglett.6b01546
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We present a metal-free [2 + 2 + 2] cyclo-addition of ynamides with nitriles that enables highly efficient access to 2,4-diaminopyridines. This catalytic protocol is more environmentally friendly and allows for a concomitant construction of C-C and C-N bonds between ynamides and nitriles, exhibiting excellent chemoselectivity, regioselectivity, and wide functional groups tolerance.
引用
收藏
页码：3390 / 3393
页数：4
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