Synthesis of Ynones via Recyclable Polystyrene-Supported Palladium(0) Complex Catalyzed Acylation of Terminal Alkynes with Acyl Chlorides under Copper- and Solvent-Free Conditions

被引：22

作者：

Bakherad, Mohammad ^{[1
]}

Keivanloo, Ali ^{[1
]}

Bahramian, Bahram ^{[1
]}

Jajarmi, Saeideh ^{[1
]}

机构：

[1] Shahrood Univ Technol, Sch Chem, Shahrood, Iran

来源：

SYNLETT | 2011年 / 03期

关键词：

copper-free; solvent-free; supported catalyst; Sonogashira coupling; acyl chloride; ynone; POT 3-COMPONENT SYNTHESIS; ACID-CHLORIDES; FERROCENYLETHYNYL KETONES; CONVENIENT SYNTHESIS; EFFICIENT SYNTHESIS; ACETYLENIC KETONES; CYCLOISOMERIZATION;

D O I：

10.1055/s-0030-1259322

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, a highly efficient method for the copper- and solvent-free coupling reaction of acyl chlorides and terminal alkynes catalyzed by 1-phenyl-1,2-propanedione-2-oxime thiosemicarbazone-functionalized polystyrene resin-supported Pd(0) complex is described. Acyl chlorides are easily coupled with terminal alkynes, giving good to high yields in the presence of a low catalyst loading (1 mol% Pd) in Et3N at room temperature under aerobic conditions. After centrifugation, the supported catalyst can be recycled and reused several times with only a slight decrease in activity.

引用

收藏

页码：311 / 314

页数：4

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