Applications of Norrish type I and II reactions in the total synthesis of natural products: a review

被引：45

作者：

Majhi, Sasadhar ^{[1
]}

机构：

[1] Kazi Nazrul Univ, Triveni Devi Bhalotia Coll, Dept Chem, UG & PG Dept, Raniganj 713347, W Bengal, India

来源：

PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES | 2021年 / 20卷 / 10期

关键词：

Drug discovery; Norrish type I and II reactions (Norrish-Yang cyclization); Pharmacological aspects; Photochemistry; Sustainable chemistry; ENANTIOSPECIFIC TOTAL-SYNTHESIS; ZARAGOZIC ACID-C; PHOTOCHEMICAL-REACTIONS; STRUCTURE ELUCIDATION; CRYSTAL-STRUCTURE; INHIBITORS; ALKALOIDS; EUNICELLIN; BIOSYNTHESIS; ANTIBIOTICS;

D O I：

10.1007/s43630-021-00100-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Natural products and their analogue have played a key role in the drug discovery and development process. In the laboratory, the total synthesis of secondary metabolites is very useful in ascertaining the hypothetical complex structure of molecules of natural origin. Total synthesis of natural products using Norrish type I and II reactions as a crucial step has been explored in this overview. Norrish reactions are important photo-induced transformations of carbonyl compounds in organic synthetic chemistry and are connected in numerous industrially and biologically relevant procedures and the processing of carbonyl compounds in the atmosphere. The present review tries to focus on the brilliant applications of Norrish type I and II photochemical reactions as a key step in the total synthesis of natural products and highlights on natural sources, structures, and biological activities of the promising natural products for the first time elegantly. Graphic abstract

引用

页码：1357 / 1378

页数：22

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