Double-Dissociation of the Catecholaminergic Modulation of Synaptic Transmission in the Oval Bed Nucleus of the Stria Terminalis

被引:39
作者
Krawczyk, Michal [1 ,2 ]
Georges, Francois [3 ,5 ]
Sharma, Robyn [1 ,2 ]
Mason, Xenos [1 ,2 ]
Berthet, Amandine [4 ,5 ]
Bezard, Erwan [4 ,5 ]
Dumont, Eric C. [1 ,2 ]
机构
[1] Queens Univ, Dept Anesthesiol & Perioperat Med, Kingston, ON K7L 3N6, Canada
[2] Queens Univ, Ctr Neurosci Studies, Kingston, ON K7L 3N6, Canada
[3] Inst Natl Sante & Rech Med, Neuroctr Magendie, U862, Bordeaux, France
[4] Ctr Natl Rech Sci, Bordeaux Inst Neurosci, UMR 5227, Bordeaux, France
[5] Univ Bordeaux, Bordeaux, France
基金
加拿大健康研究院;
关键词
VENTRAL TEGMENTAL AREA; RECEPTOR MESSENGER-RNA; EXTENDED AMYGDALA; RAT-BRAIN; ADULT-RAT; GLUTAMATERGIC TRANSMISSION; DOPAMINERGIC INNERVATION; IMMUNOREACTIVE NEURONS; INDUCED REINSTATEMENT; TYROSINE-HYDROXYLASE;
D O I
10.1152/jn.00710.2010
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Krawczyk M, Georges F, Sharma R, Mason X, Berthet A, Bezard E, Dumont EC. Double-dissociation of the catecholaminergic modulation of synaptic transmission in the oval bed nucleus of the stria terminalis. J Neurophysiol 105: 145-153, 2011. First published November 3, 2010; doi:10.1152/jn.00710.2010. The bed nucleus of the stria terminalis (BST) is a cluster of nuclei within the extended amygdala, a forebrain macrostructure with extensive projection to motor nuclei of the hindbrain. The subnuclei of the BST coordinate autonomic, neuroendocrine, and somato-motor functions and receive robust neuromodulatory monoaminergic afferents, including 5-HT-, noradrenaline (NA)-, and dopamine (DA)-containing terminals. In contrast to 5-HT and NA, little is known about how DA modulates neuronal activity or synaptic transmission in the BST. DA-containing afferents to the BST originate in the ventral tegmental area, the periaqueducal gray, and the retrorubral field. They form a fairly diffuse input to the dorsolateral BST with dense terminal fields in the oval (ovBST) and juxtacapsular (jxBST) nuclei. The efferent-afferent connectivity of the BST suggests that it may play a key role in motivated behaviors, consistent with recent evidence that the dorsolateral BST is a target for drugs of abuse. This study describes the effects of DA on synaptic transmission in the ovBST. Whole cell voltage clamp recordings were performed on ovBST neurons in brain slices from adult rats in the presence or absence of exogenous DA and receptor-targeted agonists and antagonists. The results showed that DA selectively and exclusively reduced inhibitory synaptic transmission in the ovBST in a dose-dependent and D2-like dopamine receptor-dependent manner. DA also modulated excitatory synaptic transmission in a dose-dependent dependent manner. However, this effect was mediated by alpha 2-noradrenergic receptors. Thus these data reveal a double dissociation in catecholaminergic regulation of excitatory and inhibitory synaptic transmission in the ovBST and may shed light on the mechanisms involved in neuropathological behaviors such as stress-induced relapse to consumption of drugs of abuse.
引用
收藏
页码:145 / 153
页数:9
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