Serglycin proteoglycan in hematologic malignancies: a marker of acute myeloid leukemia

被引：41
作者：
Niemann, C. U.
Kjeldsen, L.
Ralfkiaer, E.
Jensen, M. K.
Borregaard, N.
机构：
[1] Rigshosp, Dept Hematol, Copenhagen, Denmark
[2] Rigshosp, Dept Pathol, DK-2100 Copenhagen, Denmark
来源：
LEUKEMIA | 2007年 / 21卷 / 12期
关键词：
neutrophil elastase; serglycin proteoglycan; granules; AML; ALL;
D O I：
10.1038/sj.leu.2404975
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Serglycin is the major cell-associated proteoglycan of hematopoietic cells. Previous work has demonstrated that serglycin may be involved in targeting some proteins to granules of cytotoxic lymphocytes, mast cells and neutrophils. We characterized the expression of serglycin in various hematologic malignancies by immunohistochemistry and ELISA. Serglycin expression was found to distinguish acute myeloid leukemia (AML) from acute lymphoblastic leukemia. In contrast to myeloperoxidase, serglycin was found to be a selective marker for immature myeloid cells, distinguishing AML from Philadelphia chromosome-negative chronic myeloproliferative disorders.
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收藏
页码：2406 / 2410
页数：5
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