Extracellular vesicles in inflammation: Focus on the microRNA cargo of EVs in modulation of liver diseases

被引：29

作者：

Babuta, Mrigya ^{[1
]}

Szabo, Gyongyi ^{[1
]}

机构：

[1] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 2022年 / 111卷 / 01期

关键词：

biomarkers; exosomes; extracellular vesicles; inflammation; liver damage; microRNA; HEPATIC STELLATE CELLS; RNA-BINDING PROTEINS; HEPATOCELLULAR-CARCINOMA; INTERCELLULAR TRANSFER; EXOSOMAL MICRORNAS; VIRUS TRANSMISSION; TUMOR-SUPPRESSOR; HEPATOCYTE; RELEASE; EXPRESSION;

D O I：

10.1002/JLB.3MIR0321-156R

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Extracellular vesicles (EVs) are heterogeneous nanometer-ranged particles that are released by cells under both normal and pathological conditions. EV cargo comprises of DNA, protein, lipids cargo, metabolites, mRNA, and non-coding RNA that can modulate the immune system by altering inflammatory response. EV associated miRNAs contribute to the pathobiology of alcoholic liver disease, non-alcoholic liver disease, viral hepatitis, acetaminophen-induced liver injury, fibrosis, and hepatocellular carcinoma. In context of liver diseases, EVs, via their cargo, alter the inflammatory response by communicating with different cell types within the liver and between liver and other organs. Here, the role of EVs and its associated miRNA in inter-cellular communication in different liver disease and as a potential biomarker and therapeutic target is reviewed.

引用

页码：75 / 92

页数：18

共 156 条

[31] Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver [J].

Costa-Silva, Bruno ;

Aiello, Nicole M. ;

Ocean, Allyson J. ;

Singh, Swarnima ;

Zhang, Haiying ;

Thakur, Basant Kumar ;

Becker, Annette ;

Hoshino, Ayuko ;

Mark, Milica Tesic ;

Molina, Henrik ;

Xiang, Jenny ;

Zhang, Tuo ;

Theilen, Till-Martin ;

Garcia-Santos, Guillermo ;

Williams, Caitlin ;

Ararso, Yonathan ;

Huang, Yujie ;

Rodrigues, Goncalo ;

Shen, Tang-Long ;

Labori, Knut Jorgen ;

Lothe, Inger Marie Bowitz ;

Kure, Elm H. ;

Hernandez, Jonathan ;

Doussot, Alexandre ;

Ebbesen, Saya H. ;

Grandgenett, Paul M. ;

Hollingsworth, Michael A. ;

Jain, Maneesh ;

Mallya, Kavita ;

Batra, Surinder K. ;

Jarnagin, William R. ;

Schwartz, Robert E. ;

Matei, Irina ;

Peinado, Hector ;

Stanger, Ben Z. ;

Bromberg, Jacqueline ;

Lyden, David .

NATURE CELL BIOLOGY, 2015, 17 (06) :816-+

[32] Exosome mimicry by a HAVCR1-NPC1 pathway of endosomal fusion mediates hepatitis A virus infection [J].

Costafreda, Maria Isabel ;

Abbasi, Abdolrahim ;

Lu, Hsinyi ;

Kaplan, Gerardo .

NATURE MICROBIOLOGY, 2020, 5 (09) :1096-+

[33] IRE1A Stimulates Hepatocyte-Derived Extracellular Vesicles That Promote Inflammation in Mice With Steatohepatitis [J].

Dasgupta, Debanjali ;

Nakao, Yasuhiko ;

Mauer, Amy S. ;

Thompson, Jill M. ;

Sehrawat, Tejasav S. ;

Liao, Chieh-Yu ;

Krishnan, Anuradha ;

Lucien, Fabrice ;

Guo, Qianqian ;

Liu, Mengfei ;

Xue, Fei ;

Fukushima, Masanori ;

Katsumi, Tomohiro ;

Bansal, Aditya ;

Pandey, Mukesh K. ;

Maiers, Jessica L. ;

DeGrado, Timothy ;

Ibrahim, Samar H. ;

Revzin, Alexander ;

Pavelko, Kevin D. ;

Barry, Michael A. ;

Kaufman, Randal J. ;

Malhi, Harmeet .

GASTROENTEROLOGY, 2020, 159 (04) :1487-+

[34] Immature Myeloid Cells Induced by a High-Fat Diet Contribute to Liver Inflammation [J].

Deng, Zhong-bin ;

Liu, Yuelong ;

Liu, Cunren ;

Xiang, Xiaoyu ;

Wang, Jianhua ;

Cheng, Ziqiang ;

Shah, Spandan V. ;

Zhang, Shuangyin ;

Zhang, Liming ;

Zhuang, Xiaoying ;

Michalek, Sue ;

Grizzle, William E. ;

Zhang, Huang-Ge .

HEPATOLOGY, 2009, 50 (05) :1412-1420

[35] Exosome Mediated Intercellular Communication between Hepatitis C Virus-Infected Hepatocytes and Hepatic Stellate Cells (vol 91, e02225-16, 2017) [J].

Devhare, Pradip B. ;

Sasaki, Reina ;

Shrivastava, Shubham ;

Di Bisceglie, Adrian M. ;

Ray, Ranjit ;

Ray, Ratna B. .

JOURNAL OF VIROLOGY, 2017, 91 (10)

[36] Messenger-RNA-binding proteins and the messages they carry [J].

Dreyfuss, G ;

Kim, VN ;

Kataoka, N .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2002, 3 (03) :195-205

[37] Comprehensive characterization of hepatocyte-derived extracellular vesicles identifies direct miRNA-based regulation of hepatic stellate cells and DAMP-based hepatic macrophage IL-1β and IL-17 upregulation in alcoholic hepatitis mice [J].

Eguchi, Akiko ;

Yan, Rui ;

Pan, Stephanie Q. ;

Wu, Raymond ;

Kim, Jihoon ;

Chen, Yibu ;

Ansong, Charles ;

Smith, Richard D. ;

Tempaku, Mina ;

Ohno-Machado, Lucila ;

Takei, Yoshiyuki ;

Feldstein, Ariel E. ;

Tsukamoto, Hidekazu .

JOURNAL OF MOLECULAR MEDICINE-JMM, 2020, 98 (07) :1021-1034

[38] Extracellular Vesicles Released by Hepatocytes From Gastric Infusion Model of Alcoholic Liver Disease Contain a MicroRNA Barcode That Can Be Detected in Blood [J].

Eguchi, Akiko ;

Lazaro, Raul G. ;

Wang, Jiaohong ;

Kim, Jihoon ;

Povero, Davide ;

Willliams, Brandon ;

Ho, Samuel B. ;

St Arkel, Peter ;

Schnabl, Bernd ;

Ohno-Machado, Lucila ;

Tsukamoto, Hidekazu ;

Feldstein, Ariel E. .

HEPATOLOGY, 2017, 65 (02) :475-490

[39] Y-box-binding protein 1 (YB-1) and its functions [J].

Eliseeva, I. A. ;

Kim, E. R. ;

Guryanov, S. G. ;

Ovchinnikov, L. P. ;

Lyabin, D. N. .

BIOCHEMISTRY-MOSCOW, 2011, 76 (13) :1402-1433

[40] RNA packaging into extracellular vesicles: An orchestra of RNA-binding proteins? [J].

Fabbiano, Fabrizio ;

Corsi, Jessica ;

Gurrieri, Elena ;

Trevisan, Caterina ;

Notarangelo, Michela ;

D'Agostino, Vito G. .

JOURNAL OF EXTRACELLULAR VESICLES, 2020, 10 (02)

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