Human cholesteryl ester transport protein transgene promotes macrophage reverse cholesterol transport in C57BL/6 mice and phospholipid transfer protein gene knockout mice
被引:6
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作者:
Liu, Na
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机构:
Weifang Med Univ, Inst Lipid Metab & Atherosclerosis, Sch Pharm, Innovat Drug Res Ctr, Weifang 261053, Peoples R ChinaWeifang Med Univ, Inst Lipid Metab & Atherosclerosis, Sch Pharm, Innovat Drug Res Ctr, Weifang 261053, Peoples R China
Liu, Na
[1
]
Si, Yanhong
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机构:
Shandong First Med Univ, Inst Atherosclerosis, Key Lab Atherosclerosis Univ Shandong Prov, Tai An 271000, Shandong, Peoples R China
Shandong Acad Med Sci, Tai An 271000, Shandong, Peoples R ChinaWeifang Med Univ, Inst Lipid Metab & Atherosclerosis, Sch Pharm, Innovat Drug Res Ctr, Weifang 261053, Peoples R China
Si, Yanhong
[2
,3
]
Zhang, Ying
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机构:
Shandong First Med Univ, Inst Atherosclerosis, Key Lab Atherosclerosis Univ Shandong Prov, Tai An 271000, Shandong, Peoples R China
Shandong Acad Med Sci, Tai An 271000, Shandong, Peoples R ChinaWeifang Med Univ, Inst Lipid Metab & Atherosclerosis, Sch Pharm, Innovat Drug Res Ctr, Weifang 261053, Peoples R China
Zhang, Ying
[2
,3
]
Guo, Shoudong
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机构:
Weifang Med Univ, Inst Lipid Metab & Atherosclerosis, Sch Pharm, Innovat Drug Res Ctr, Weifang 261053, Peoples R China
Shandong First Med Univ, Inst Atherosclerosis, Key Lab Atherosclerosis Univ Shandong Prov, Tai An 271000, Shandong, Peoples R China
Shandong Acad Med Sci, Tai An 271000, Shandong, Peoples R ChinaWeifang Med Univ, Inst Lipid Metab & Atherosclerosis, Sch Pharm, Innovat Drug Res Ctr, Weifang 261053, Peoples R China
Guo, Shoudong
[1
,2
,3
]
Qin, Shucun
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机构:
Weifang Med Univ, Inst Lipid Metab & Atherosclerosis, Sch Pharm, Innovat Drug Res Ctr, Weifang 261053, Peoples R ChinaWeifang Med Univ, Inst Lipid Metab & Atherosclerosis, Sch Pharm, Innovat Drug Res Ctr, Weifang 261053, Peoples R China
Qin, Shucun
[1
]
机构:
[1] Weifang Med Univ, Inst Lipid Metab & Atherosclerosis, Sch Pharm, Innovat Drug Res Ctr, Weifang 261053, Peoples R China
[2] Shandong First Med Univ, Inst Atherosclerosis, Key Lab Atherosclerosis Univ Shandong Prov, Tai An 271000, Shandong, Peoples R China
[3] Shandong Acad Med Sci, Tai An 271000, Shandong, Peoples R China
Cholesteryl ester transfer protein (CETP) and phospholipid transfer protein (PLTP) belong to the same gene family. Liver-specific expression of CETP improves reverse cholesterol transport (RCT) and PLTP knockout (KO) decreases RCT in mice. In this study, we investigate the effect of CETP transgene (CETP-tg) on RCT and whether CETP-tg can partially restore RCT efficiency in PLTP KO mice. Several rounds of crossing were carried out to produce colonies of wild type (WT), CETP-tg, PLTP KO, and CETP-tg x PLTP KO mice were obtained after several generations of reproduction. The efficiency of RCT was detected using [H-3]-cholesterol-laden macrophages, and the underlying mechanisms were investigated by multiple techniques. Our data demonstrated that CETP-tg significantly increased the transport rate of [H-3]-cholesterol from macrophages to plasma and liver, and finally the excretion through feces compared to the WT littermates. The RCT improving effect of CETP-tg was similar in PLTPKO mice. Furthermore, CETP-tg did not affect the expression of RCT-related proteins, such as low-density lipoprotein receptor. The mechanisms of improving RCT may be attributed to the low level of oxidized lipids in CETP-tg mouse and CETP-mediated lipid transport. Collectively, CETP-tg improves RCT in mice, and CETP can not compensate for PLTP deficiency.
机构:
Shandong Univ, Key Lab Atherosclerosis, Tai An 271000, Shandong, Peoples R China
Taishan Med Univ, Inst Atherosclerosis, Tai An 271000, Shandong, Peoples R ChinaShandong Univ, Key Lab Atherosclerosis, Tai An 271000, Shandong, Peoples R China
Si, Yanhong
Zhang, Ying
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机构:
Shandong Univ, Key Lab Atherosclerosis, Tai An 271000, Shandong, Peoples R China
Taishan Med Univ, Inst Atherosclerosis, Tai An 271000, Shandong, Peoples R ChinaShandong Univ, Key Lab Atherosclerosis, Tai An 271000, Shandong, Peoples R China
Zhang, Ying
Chen, Xiaofeng
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机构:
Shandong Univ, Key Lab Atherosclerosis, Tai An 271000, Shandong, Peoples R China
Taishan Med Univ, Inst Atherosclerosis, Tai An 271000, Shandong, Peoples R ChinaShandong Univ, Key Lab Atherosclerosis, Tai An 271000, Shandong, Peoples R China
Chen, Xiaofeng
Zhai, Lei
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机构:
Shandong Univ, Key Lab Atherosclerosis, Tai An 271000, Shandong, Peoples R China
Taishan Med Univ, Inst Atherosclerosis, Tai An 271000, Shandong, Peoples R ChinaShandong Univ, Key Lab Atherosclerosis, Tai An 271000, Shandong, Peoples R China
Zhai, Lei
Zhou, Guanghai
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机构:
Shandong Univ, Key Lab Atherosclerosis, Tai An 271000, Shandong, Peoples R China
Taishan Med Univ, Inst Atherosclerosis, Tai An 271000, Shandong, Peoples R ChinaShandong Univ, Key Lab Atherosclerosis, Tai An 271000, Shandong, Peoples R China
Zhou, Guanghai
Yu, Ailing
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机构:
Taian Ctr Hosp, Tai An 271000, Shandong, Peoples R ChinaShandong Univ, Key Lab Atherosclerosis, Tai An 271000, Shandong, Peoples R China
Yu, Ailing
Cao, Haijun
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机构:
Taian Ctr Hosp, Tai An 271000, Shandong, Peoples R ChinaShandong Univ, Key Lab Atherosclerosis, Tai An 271000, Shandong, Peoples R China
Cao, Haijun
Qin Shucun
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机构:
Shandong Univ, Key Lab Atherosclerosis, Tai An 271000, Shandong, Peoples R China
Taishan Med Univ, Inst Atherosclerosis, Tai An 271000, Shandong, Peoples R ChinaShandong Univ, Key Lab Atherosclerosis, Tai An 271000, Shandong, Peoples R China
机构:
Univ Sao Paulo, Lipids Lab LIM 10, Fac Med Sci, BR-01246000 Sao Paulo, BrazilUniv Sao Paulo, Lipids Lab LIM 10, Fac Med Sci, BR-01246000 Sao Paulo, Brazil
Rocco, D. D. F. M.
Okuda, L. S.
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Univ Sao Paulo, Lipids Lab LIM 10, Fac Med Sci, BR-01246000 Sao Paulo, BrazilUniv Sao Paulo, Lipids Lab LIM 10, Fac Med Sci, BR-01246000 Sao Paulo, Brazil
Okuda, L. S.
Pinto, R. S.
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Univ Sao Paulo, Lipids Lab LIM 10, Fac Med Sci, BR-01246000 Sao Paulo, BrazilUniv Sao Paulo, Lipids Lab LIM 10, Fac Med Sci, BR-01246000 Sao Paulo, Brazil
Pinto, R. S.
Ferreira, F. D.
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Univ Sao Paulo, Lipids Lab LIM 10, Fac Med Sci, BR-01246000 Sao Paulo, BrazilUniv Sao Paulo, Lipids Lab LIM 10, Fac Med Sci, BR-01246000 Sao Paulo, Brazil
Ferreira, F. D.
Kubo, S. K.
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Univ Sao Paulo, Emergency Care Res Unit LIM 51, Fac Med Sci, BR-01246000 Sao Paulo, BrazilUniv Sao Paulo, Lipids Lab LIM 10, Fac Med Sci, BR-01246000 Sao Paulo, Brazil
Kubo, S. K.
Nakandakare, E. R.
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Univ Sao Paulo, Lipids Lab LIM 10, Fac Med Sci, BR-01246000 Sao Paulo, BrazilUniv Sao Paulo, Lipids Lab LIM 10, Fac Med Sci, BR-01246000 Sao Paulo, Brazil
Nakandakare, E. R.
Quintao, E. C. R.
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Univ Sao Paulo, Lipids Lab LIM 10, Fac Med Sci, BR-01246000 Sao Paulo, BrazilUniv Sao Paulo, Lipids Lab LIM 10, Fac Med Sci, BR-01246000 Sao Paulo, Brazil
Quintao, E. C. R.
Catanozi, S.
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Univ Sao Paulo, Lipids Lab LIM 10, Fac Med Sci, BR-01246000 Sao Paulo, BrazilUniv Sao Paulo, Lipids Lab LIM 10, Fac Med Sci, BR-01246000 Sao Paulo, Brazil
Catanozi, S.
Passarelli, M.
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Univ Sao Paulo, Lipids Lab LIM 10, Fac Med Sci, BR-01246000 Sao Paulo, BrazilUniv Sao Paulo, Lipids Lab LIM 10, Fac Med Sci, BR-01246000 Sao Paulo, Brazil
机构:
Univ Penn, Perelman Sch Med, Div Translat Med & Human Genet, Philadelphia, PA 19104 USAUniv Penn, Perelman Sch Med, Div Translat Med & Human Genet, Philadelphia, PA 19104 USA
Kuwano, Takashi
Bi, Xin
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机构:
Univ Penn, Perelman Sch Med, Div Translat Med & Human Genet, Philadelphia, PA 19104 USAUniv Penn, Perelman Sch Med, Div Translat Med & Human Genet, Philadelphia, PA 19104 USA
Bi, Xin
Cipollari, Eleonora
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Univ Penn, Perelman Sch Med, Div Translat Med & Human Genet, Philadelphia, PA 19104 USAUniv Penn, Perelman Sch Med, Div Translat Med & Human Genet, Philadelphia, PA 19104 USA
Cipollari, Eleonora
Yasuda, Tomoyuki
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Univ Penn, Perelman Sch Med, Div Translat Med & Human Genet, Philadelphia, PA 19104 USAUniv Penn, Perelman Sch Med, Div Translat Med & Human Genet, Philadelphia, PA 19104 USA
Yasuda, Tomoyuki
Lagor, William R.
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机构:
Univ Penn, Perelman Sch Med, Div Translat Med & Human Genet, Philadelphia, PA 19104 USAUniv Penn, Perelman Sch Med, Div Translat Med & Human Genet, Philadelphia, PA 19104 USA
Lagor, William R.
Szapary, Hannah J.
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Univ Penn, Perelman Sch Med, Div Translat Med & Human Genet, Philadelphia, PA 19104 USAUniv Penn, Perelman Sch Med, Div Translat Med & Human Genet, Philadelphia, PA 19104 USA
Szapary, Hannah J.
Tohyama, Junichiro
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h-index: 0
机构:
Univ Penn, Perelman Sch Med, Div Translat Med & Human Genet, Philadelphia, PA 19104 USAUniv Penn, Perelman Sch Med, Div Translat Med & Human Genet, Philadelphia, PA 19104 USA
Tohyama, Junichiro
Millar, John S.
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Univ Penn, Perelman Sch Med, Div Translat Med & Human Genet, Philadelphia, PA 19104 USAUniv Penn, Perelman Sch Med, Div Translat Med & Human Genet, Philadelphia, PA 19104 USA
Millar, John S.
Billheimer, Jeffrey T.
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Univ Penn, Perelman Sch Med, Div Translat Med & Human Genet, Philadelphia, PA 19104 USAUniv Penn, Perelman Sch Med, Div Translat Med & Human Genet, Philadelphia, PA 19104 USA
Billheimer, Jeffrey T.
Lyssenko, Nicholas N.
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Univ Penn, Perelman Sch Med, Div Translat Med & Human Genet, Philadelphia, PA 19104 USAUniv Penn, Perelman Sch Med, Div Translat Med & Human Genet, Philadelphia, PA 19104 USA
Lyssenko, Nicholas N.
Rader, Daniel J.
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机构:
Univ Penn, Perelman Sch Med, Div Translat Med & Human Genet, Philadelphia, PA 19104 USA
Univ Penn, Perelman Sch Med, Dept Med, Philadelphia, PA 19104 USA
Univ Penn, Perelman Sch Med, Dept Genet, Philadelphia, PA 19104 USAUniv Penn, Perelman Sch Med, Div Translat Med & Human Genet, Philadelphia, PA 19104 USA