Crosslinker-Free Hyaluronic Acid Aerogels

被引：13

作者：

Aguilera-Bulla, Daniel ^{[1
]}

Legay, Laurianne ^{[1
]}

Buwalda, Sytze J. ^{[1
]}

Budtova, Tatiana ^{[1
]}

机构：

[1] PSL Res Univ, Ctr Mat Forming CEMEF, MINES Paris, UMR CNRS 7635, F-06904 Sophia Antipolis, France

来源：

BIOMACROMOLECULES | 2022年 / 23卷 / 07期

关键词：

BEHAVIOR; CARRIER; PH;

D O I：

10.1021/acs.biomac.2c00207

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aerogels based on hyaluronic acid (HA) were prepared without any chemical crosslinking by polymer dissolution, network formation via nonsolvent-induced phase separation, and supercritical CO2 drying. The influence of solution pH, concentration of HA, and type of nonsolvent on network volume shrinkage, aerogel density, morphology, and specific surface area was investigated. A marked dependence of aerogel properties on solution pH was observed: aerogels with the highest specific surface area, 510 m(2)/g, and the lowest density, 0.057 g/cm(3), were obtained when the HA solution was at its isoelectric point (pH 2.5). This work reports the first results ever on neat HA aerogels and constitutes the background for their use as advanced materials for biomedical applications.

引用

页码：2838 / 2845

页数：8

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