Gypenosides protects dopaminergic neurons in primary culture against MPP+-induced oxidative injury

被引：47

作者：

Wang, Peng ^{[3
]}

Niu, Le ^{[2
]}

Guo, Xiao-Dong ^{[1
]}

Gao, Li ^{[3
]}

Li, Wei-Xin ^{[3
]}

Jia, Dong ^{[3
]}

Wang, Xue-Lian ^{[3
]}

Ma, Lian-Ting ^{[1
]}

Gao, Guo-Dong ^{[3
]}

机构：

[1] Wuhan Gen Hosp, Guangzhou Command PLA, Dept Neurosurg, Wuhan 430070, Peoples R China

[2] Fourth Mil Med Univ, Dept Anat Histol & Embryol, Xian 710038, Peoples R China

[3] Fourth Mil Med Univ, Tangdu Hosp, Dept Neurosurg, Xian 710038, Peoples R China

来源：

BRAIN RESEARCH BULLETIN | 2010年 / 83卷 / 05期

基金：

中国博士后科学基金;

关键词：

Gypenosides; Neuroprotection; Neurotoxicity; Substantia nigra; Parkinson s disease; PARKINSONS-DISEASE; SUBSTANTIA-NIGRA; BRAIN; MECHANISMS; GLUTATHIONE; NEUROTOXIN; MPTP; MITOCHONDRIA; INHIBITION; ACTIVATION;

D O I：

10.1016/j.brainresbull.2010.06.014

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Oxidative injury has been implicated in the etiology of Parkinson s disease (PD) Gypenosides (GPs) the saponins extract derived from the Gynostemma pentaphyllum has various bioactivities In this study GPs was investigated for its neuroprotective effects on the 1-methyl-4-phenylpyridinium ion (MPP+)-induced oxidative injury of dopaminergic neurons in primary nigral culture It was found that GPs pretreatment cotreatment or posttreatment significantly and dose-dependently attenuated MPP+-induced oxidative damage reduction of dopamine uptake loss of tyrosine hydrolase (TH)-immunopositive neurons and degeneration of TH-immunopositive neurites However the preventive effect of GPs was more potential than its therapeutical effect Most importantly the neuroprotective effect of GPs may be attributed to GPs-induced strengthened antioxidation as manifested by significantly increased glutathione content and enhanced activity of glutathione peroxidase catalyze and superoxide dismutase in nigral culture The neuroprotective effects of GPs are specific for dopaminergic neurons and it may have therapeutic potential in the treatment of PD (C) 2010 Elsevier Inc All rights reserved

引用

页码：266 / 271

页数：6

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