Serum ascorbic acid and other correlates of gallbladder disease among US adults

被引：24
作者：
Simon, JA
Hudes, ES
机构：
[1] Vet Affairs Med Ctr, Med Serv, Gen Internal Med Sect, San Francisco, CA 94121 USA
[2] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA
来源：
AMERICAN JOURNAL OF PUBLIC HEALTH | 1998年 / 88卷 / 08期
关键词：
D O I：
10.2105/AJPH.88.8.1208
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Objectives. This study examined the correlates of clinical gallbladder disease among US adults aed whether serum ascorbic acid levels ara associated with a decreased prevalence of gallbladder disease. Methods. Cross-sectional analyses of data from the Second National Health and Nutrition Examination Survey were conducted. Results. A total of 384 women (8%) and 107 men (3%) reported a history of gallstone disease, and 347 women (7%) and 81 men (2%) reported a history, of cholecystectomy. An inverted U-shaped relation was found between serum ascorbic acid level and clinical gallbladder disease among women but not among men. Conclusions. Ascorbic acid which affects the catabolism of cholesterol to bile acids and in turn, the development of gallbladder disease iu experimental animals, may reduce the risk of clinical gallbladder disease in humans.
引用
收藏
页码：1208 / 1212
页数：5
相关论文
共 31 条
  • [1] ANGELICO M, 1988, HEPATOLOGY, V8, P907
  • [2] [Anonymous], LAB PROCEDURES USED
  • [3] [Anonymous], 1992, NIH CONSENS STATEMEN, V10, P1
  • [4] BERGMAN F, 1981, MED BIOL, V59, P92
  • [5] BJORKHEM I, 1976, J LIPID RES, V17, P360
  • [6] ROBUST LOCALLY WEIGHTED REGRESSION AND SMOOTHING SCATTERPLOTS
    CLEVELAND, WS
    [J]. JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION, 1979, 74 (368) : 829 - 836
  • [7] DIEHL AK, 1991, GASTROENTEROL CLIN N, V20, P1
  • [8] FREI B, 1990, ADV EXP MED BIOL, V264, P155
  • [9] FULWOOD R, 1987, JAMA-J AM MED ASSOC, V257, P937
  • [10] Ginter E, 1982, Int J Vitam Nutr Res Suppl, V23, P137
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