N-terminal processing:: the methionine aminopeptidase and Nα-acetyl transferase families

被引：412

作者：

Bradshaw, RA ^{[1
]}

Brickey, WW

Walker, KW

机构：

[1] Univ Calif Irvine, Coll Med, Dept Physiol & Biophys, Irvine, CA 92697 USA

[2] Univ Calif Irvine, Coll Med, Dept Neurobiol & Anat, Irvine, CA 92697 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1998年 / 23卷 / 07期

关键词：

D O I：

10.1016/S0968-0004(98)01227-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Removal of the initiator methionine and/or acetylation of the alpha-amino group are among the earliest possible chemical modifications that occur during protein synthesis in eukaryotes. These events are catalyzed by methionine aminopeptidase and N-alpha-acetyltransferase respectively. Recent advances in the isolation and characterization of these enzymes indicate that they exist as isoforms that vary in cellullar location, function, and evolutionary origins.

引用

页码：263 / 267

页数：5

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