Dietary shochu kasu alleviates fatty liver induced by orotic acid

被引：2
|
作者：
Buang, Yohanes [1 ,2 ]
Ola, Pius D. [2 ]
Yanagita, Teruyoshi [1 ]
机构：
[1] Saga Univ, Dept Appl Biol Sci, Lab Appl Biochem, Saga, Japan
[2] Nusa Cendana Univ, Dept Chem, Fac Sci & Engn, Kupang, Indonesia
来源：
BANGLADESH JOURNAL OF PHARMACOLOGY | 2010年 / 5卷 / 01期
关键词：
Fatty liver; Orotic acid; Triacylglycerol; Shochu kasu; NONALCOHOLIC STEATOHEPATITIS; PHOSPHATIDATE PHOSPHOHYDROLASE; DISTILLERY WASTE; RATS; ACCUMULATION; FIBROSIS;
D O I：
10.3329/bjp.v5i1.5921
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effects of dietary shochu kasu (5%) on orotic acid-induced fatty liver were studied in rats. Liver triglyceride content of orotic acid-fed rats increased by 5-fold in comparison to basal group. Shochu kasu reduced triglyceride content by two-third. The activities of fatty acid synthase and phosphatidate phosphohydrolase significantly decreased, that was approximately by 35% and 20%, respectively. The serum lipid levels however were nearly unchanged. The alleviation of fatty liver in rats with shochu kasu, therefore, was associated with the inhibition of fatty acid synthase and phosphatidate phosphohydrolase activities.
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页码：57 / 61
页数：5
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