Autonomous in Vitro Anticancer Drug Release from Mesoporous Silica Nanoparticles by pH-Sensitive Nanovalves

被引：523

作者：

Meng, Huan ^{[2
]}

Xue, Min ^{[1
]}

Xia, Tian ^{[2
]}

Zhao, Yan-Li ^{[6
]}

Tamanoi, Fuyuhiko ^{[3
,4
]}

Stoddart, J. Fraser ^{[6
]}

Zink, Jeffrey I. ^{[1
,4
]}

Nel, Andre E. ^{[2
,4
,5
]}

机构：

[1] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Dept Med, Div NanoMed, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA

[4] Univ Calif Los Angeles, Calif NanoSyst Inst, Los Angeles, CA 90095 USA

[5] Univ Calif Los Angeles, So Calif Particle Ctr, Los Angeles, CA 90095 USA

[6] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 36期

基金：

比尔及梅琳达.盖茨基金会; 美国国家科学基金会;

关键词：

POLYMERIC MICELLE; H+-ATPASE; DELIVERY; CELLS; COMPARTMENTS; INHIBITORS; NH4CL;

D O I：

10.1021/ja104501a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Mesoporous silica nanoparticles (MSNP) have proven to be an extremely effective solid support for controlled drug delivery on account of the fact that their surfaces can be easily functionalized in order to control the nanopore openings. We have described recently a series of mechanized silica nanoparticles, which, under abiotic conditions, are capable of delivering cargo molecules employing a series of nanovalves. The key question for these systems has now become whether they can be adapted for biological use through controlled nanovalve opening in cells. Herein, we report a novel MSNP delivery system capable of drug delivery based on the function of beta-cyclodextrin (beta-CD) nanovalves that are responsive to the endosomal acidification conditions in human differentiated myeloid (THP-1) and squamous carcinoma (KB-31) cell lines. Furthermore, we demonstrate how to optimize the surface functionalization of the MSNP so as to provide a platform for the effective and rapid doxorubicin release to the nuclei of KB-31 cells.

引用

页码：12690 / 12697

页数：8

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