The relationship between smooth pursuit eye movements and tardive dyskinesia in schizophrenia

Objective: To examine the relationship between smooth pursuit eye movements and tar dive dyskinesia (TD) in schizophrenia. Methods: Forty schizophrenic patients with TD and 25 non-TD patients had smooth pursuit eye movements tested with infrared oculography. In addition to the diagnosis of TD (present or absent), each patient had ratings of severity of TD. Results: There was no significant or strong association between TD and poor smooth pursuit eye movements. Conclusion: The results stand in contrast to those of several previous studies, which were based on limited methodology. However, this study was not al,le to exclude definitively the possibility that TD is associated with poor smooth pursuit, perhaps with a small to moderate effect. Furthermore, these conclusions are limited to simple eye tracking protocols in which distractions are minimized. The question of whether or not TD is associated with poor smooth pursuit in schizophrenia needs to be resurrected. (C) 1998 Elsevier Science B.V. All rights reserved.