Synthesis of Functionalized Pyridines via a Regioselective Oxazoline Promoted C-H Amidation Reaction

被引：28
|
作者：
Maiden, Tracy M. M. [1 ]
Swanson, Stephen [2 ]
Procopiou, Panayiotis A. [2 ]
Harrity, Joseph P. A. [1 ]
机构：
[1] Univ Sheffield, Dept Chem, Sheffield S3 7HF, S Yorkshire, England
[2] GlaxoSmithKline, Stevenage SG1 2NY, Herts, England
来源：
ORGANIC LETTERS | 2016年 / 18卷 / 14期
基金：
英国工程与自然科学研究理事会;
关键词：
CROSS-COUPLING REACTIONS; DIRECTING GROUPS; AMINATION; DERIVATIVES; QUINAZOLINES; HETEROARENES; HETEROCYCLES; ACTIVATION; INHIBITORS; ARENES;
D O I：
10.1021/acs.orglett.6b01612
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The first Rh-catalyzed C-H amidation of pyridines is reported. The incorporation of a substituent at the C-2 position both is crucial to the success of this transformation and provides considerable scope for further elaboration of the resulting products. Among these compounds, 2-chloropyridines allow access to a selection of intermediates including a versatile azaquinazoline scaffold.
引用
收藏
页码：3434 / 3437
页数：4
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