The Relation Between Atherosclerosis and the Neutrophil-Lymphocyte Ratio

被引：283

作者：

Balta, Sevket ^{[1
]}

Celik, Turgay ^{[2
]}

Mikhailidis, Dimitri P. ^{[3
]}

Ozturk, Cengiz ^{[2
]}

Demirkol, Sait ^{[2
]}

Aparci, Mustafa ^{[4
]}

Iyisoy, Atila ^{[2
]}

机构：

[1] Eskisehir Mil Hosp, Dept Cardiol, Eskisehir, Turkey

[2] Gulhane Mil Med Acad, Dept Cardiol, Ankara, Turkey

[3] UCL, Dept Clin Biochem, Univ Coll London Med Sch London, London, England

[4] Etimesgut Mil Hosp, Dept Cardiol, Ankara, Turkey

来源：

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS | 2016年 / 22卷 / 05期

关键词：

neutrophil-lymphocyte ratio; atherosclerosis; inflammation; PERCUTANEOUS CORONARY INTERVENTION; MEAN PLATELET VOLUME; CELL DISTRIBUTION WIDTH; ELEVATED MYOCARDIAL-INFARCTION; ADVERSE CARDIAC EVENTS; INTIMA-MEDIA THICKNESS; CHRONIC KIDNEY-DISEASE; LONG-TERM MORTALITY; NEUTROPHIL/LYMPHOCYTE RATIO; ARTERY-DISEASE;

D O I：

10.1177/1076029615569568

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Inflammation plays an important role in the pathophysiology of vascular disease. In this review, we consider the associations between the neutrophil-lymphocyte ratio (NLR; an indicator of inflammation) and vascular disease and its associated risk factors. The NLR has received attention due to its role as an independent prognostic factor for coronary artery disease. The NLR can also be affected by atherosclerotic risk factors, such as hypercholesterolemia, metabolic syndrome, diabetes, and hypertension. Importantly, it can predict mortality in cardiovascular diseases. There are also reports of a positive correlation between the NLR and commonly used inflammatory markers. Inflammation is important not only in pathophysiology but also clinical outcomes of many diseases. The NLR is a widely available, easily derived, and reproducible marker of inflammation. Unlike many other inflammatory markers, the NLR is inexpensive and readily available and it provides additional risk stratification beyond conventional risk scores.

引用

页码：405 / 411

页数：7

共 75 条

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