Comparison of the Efficiency of Transplantation of Rat and Human Olfactory Ensheathing Cells in Posttraumatic Cysts of the Spinal Cord

被引：3
|
作者：
Voronova, A. D. [1 ,2 ]
Stepanova, O., V [1 ]
Valikhov, M. P. [1 ]
Chadin, A., V [1 ]
Semkina, A. S. [2 ]
Abakumov, M. A. [2 ]
Reshetov, I., V [3 ]
Chekhonin, V. P. [1 ,2 ]
机构：
[1] Minist Hlth Russian Federat, Dept Fundamental & Appl Neurobiol, VP Serbsky Natl Med Res Ctr Psychiat & Narcol, Moscow, Russia
[2] NI Pirogov Natl Res Med Univ, Minist Hlth Russian Federat, Dept Med Nanobiotechnol, Med & Biol Fac, Moscow, Russia
[3] IM Sechenov First Moscow State Med Univ, Univ Hosp 1, Minist Hlth Russian Federat, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2019年 / 167卷 / 04期
基金：
俄罗斯科学基金会;
关键词：
olfactory ensheathing cells; olfactory mucosa; cell therapy; cysts of spinal cord; spinal cord injury; INJURY; SYRINGOMYELIA; RECOVERY; REPAIR; TISSUE;
D O I：
10.1007/s10517-019-04568-z
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Olfactory ensheathing cells showed significant effects on the regeneration of the spinal cord in experimental models and in clinical trials. However, the use of these cells in the therapy of posttraumatic cysts of the spinal cord has not been studied. Cultures of human and rat olfactory mucosa were obtained according to the protocols developed by us. Passage 3-4 cultures are most enriched with olfactory ensheathing cells and are preferable for transplantation. We performed transplantation of 750,000 olfactory ensheathing cells into the region of modeled cysts. The therapeutic effect of human cells was more pronounced. The positive dynamics of recovery of motor activity in the hind limbs of rats can reflect regenerative processes in the spinal cord after transplantation of olfactory ensheathing cells into the region of posttraumatic cysts.
引用
收藏
页码：536 / 540
页数：5
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