Three-TeslaMRI does not improve the diagnosis of multiple sclerosis A multicenter study

被引：31

作者：

Hagens, Marloes H. J. ^{[1
]}

Burggraaff, Jessica ^{[1
]}

Kilsdonk, Iris D. ^{[2
,4
]}

de Vos, Marlieke L. ^{[2
]}

Cawley, Niamh ^{[5
]}

Sbardella, Emilia ^{[8
]}

Andelova, Michaela ^{[9
]}

Amann, Michael ^{[9
,10
,11
]}

Lieb, Johanna M. ^{[10
]}

Pantano, Patrizia ^{[8
,12
]}

Lissenberg-Witte, Birgit I. ^{[3
]}

Killestein, Joep ^{[1
]}

Oreja-Guevara, Celia ^{[13
]}

Ciccarelli, Olga ^{[5
,14
]}

Gasperini, Claudio ^{[15
]}

Lukas, Carsten ^{[16
]}

Wattjes, Mike P. ^{[2
]}

Barkhof, Frederik ^{[2
,6
,7
,14
]}

机构：

[1] Vrije Univ Amsterdam, Med Ctr, MS Ctr Amsterdam, Dept Neurol, Amsterdam, Netherlands

[2] Vrije Univ Amsterdam, Med Ctr, MS Ctr Amsterdam, Dept Radiol & Nucl Med, Amsterdam, Netherlands

[3] Vrije Univ Amsterdam, Med Ctr, Dept Epidemiol & Biostat, Amsterdam, Netherlands

[4] Onze Lieve Vrouwen Gasthuis, Dept Radiol & Nucl Med, Amsterdam, Netherlands

[5] UCL Inst Neurol, Queen Sq Multiple Sclerosis Ctr, London, England

[6] UCL Inst Neurol, Inst Neurol, London, England

[7] UCL Inst Neurol, Inst Healthcare Engn, London, England

[8] Sapienza Univ Rome, Dept Neurol & Psychiat, Rome, Italy

[9] Univ Hosp Basel, Dept Neurol, Basel, Switzerland

[10] Univ Hosp Basel, Div Neuroradiol, Dept Radiol, Basel, Switzerland

[11] Med Image Anal Ctr, Basel, Switzerland

[12] Ist Neurol Mediterraneo, Neuromed, Pozzilli, IS, Italy

[13] Hosp Clin San Carlos IdISSC, Inst Invest Sanitaria, Hosp Clin San Carlos, Dept Neurol, Madrid, Spain

[14] UCLH, BRC, Natl Inst Hlth Res, London, England

[15] San Camillo Forlanini Hosp, Dept Neurosci, Rome, Italy

[16] Ruhr Univ, St Josef Hosp, Dept Diagnost & Intervent Radiol & Nucl Med, Bochum, Germany

来源：

NEUROLOGY | 2018年 / 91卷 / 03期

关键词：

HIGH-FIELD MRI; MAGNIMS CONSENSUS GUIDELINES; LESION DETECTION; CRITERIA; MS; DISABILITY; IMPACT; BRAIN;

D O I：

10.1212/WNL.0000000000005825

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective In the work-up of patients presenting with a clinically isolated syndrome (CIS), 3T MRI might offer a higher lesion detection than 1.5T, but it remains unclear whether this affects the fulfilment of the diagnostic criteria for multiple sclerosis (MS). Methods We recruited 66 patients with CIS within 6 months from symptom onset and 26 healthy controls in 6MS centers. All participants underwent 1.5T and 3T brain and spinal cord MRI at baseline according to local optimized protocols and the MAGNIMS guidelines. Patients who had not converted to MS during follow-up received repeat brain MRI at 3-6 months and 12-15 months. The number of lesions per anatomical region was scored by 3 raters in consensus. Criteria for dissemination in space (DIS) and dissemination in time (DIT) were determined according to the 2017 revisions of the McDonald criteria. Results Three-Tesla MRI detected 15% more T2 brain lesions compared to 1.5T (p < 0.001), which was driven by an increase in baseline detection of periventricular (12%, p = 0.015), (juxta) cortical (21%, p = 0.005), and deep white matter lesions (21%, p < 0.001). The detection rate of spinal cord lesions and gadolinium-enhancing lesions did not differ between field strengths. Three-Tesla MRI did not lead to a higher number of patients fulfilling the criteria for DIS or DIT, or subsequent diagnosis of MS, at any of the 3 time points. Conclusion Scanning at 3T does not influence the diagnosis of MS according to McDonald diagnostic criteria.

引用

页码：E249 / E257

页数：9