A model of wound healing in chronically radiation-damaged rat skin

被引：13
作者：
Schwentker, A
Evans, SM
Partington, M
Johnson, BL
Koch, CJ
Thom, SR [1 ]
机构：
[1] Univ Penn, Med Ctr, Dept Dermatol, Philadelphia, PA 19104 USA
[2] Univ Penn, Med Ctr, Dept Surg, Philadelphia, PA 19104 USA
[3] Univ Penn, Med Ctr, Dept Radiat Oncol, Philadelphia, PA 19104 USA
[4] Univ Penn, Inst Environm Med, Philadelphia, PA 19104 USA
来源：
CANCER LETTERS | 1998年 / 128卷 / 01期
关键词：
radiotherapy; angiogenesis; malignancy;
D O I：
10.1016/S0304-3835(98)00053-6
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The aim of this investigation was to develop a model for studying the chronic effects of radiation on wound healing in the rat. Six months after rats received a single radiation exposure of 20 Gy, a random-pattern dorsal skin flap was elevated. Two weeks after the flap was elevated, irradiated animals showed diminished scar formation and wound breaking strength, as compared with controls (P < 0.05). The effect of hyperbaric oxygen treatment was investigated in some rats who received 20 sessions at 2.4 atmospheres absolute for 90 min daily, 5 days per week, prior to flap elevation and 10 sessions after creation of the flap. Treated animals showed a trend toward improvements in wound breaking strength and scar formation (P = 0.06). A reproducible model of chronic radiation damage in the rat was established. Further studies involving investigations at times more that 2 weeks post-wounding are needed. (C) 1998 Elsevier Science Ireland Ltd.
引用
收藏
页码：71 / 78
页数：8
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