Chiral resolution of multichiral center racemates by different modalities of chromatography

被引：24

作者：

Ali, Imran ^{[1
]}

Suhail, Mohd ^{[1
]}

Lone, Mohammad Nadeem ^{[1
]}

Alothman, Zeid A. ^{[2
]}

Alwarthan, Abdulrahman ^{[2
]}

机构：

[1] Jamia Millia Islamia, Dept Chem, New Delhi, India

[2] King Saud Univ, Dept Chem, Coll Sci, Riyadh, Saudi Arabia

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES | 2016年 / 39卷 / 09期

关键词：

Chiral selectors; chromatographic modalities; future challenges; future prospective; multichiral center racemates; SUPERCRITICAL-FLUID CHROMATOGRAPHY; 4 OPTICAL ISOMERS; ENANTIOMERIC RESOLUTION; NORMAL-PHASE; SELF-DISPROPORTIONATION; LIQUID-CHROMATOGRAPHY; STATIONARY-PHASE; BETA-BLOCKERS; CAPILLARY ELECTROCHROMATOGRAPHY; DILTIAZEM HYDROCHLORIDE;

D O I：

10.1080/10826076.2016.1152582

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

It is a continuous chase of researchers to separate chiral racemates due to their dominance in the pharmaceutical industry, agrochemicals, and food additives. There are many analytical techniques which have been used to resolve one chiral center racemates, but, little the literature report is scanty for the resolution of multiple stereogenic center racemates. Therefore, in this article the efforts were made to describe the enantiomeric resolution of multiple stereogenic center racemates by different modalities of chromatography. The various modalities discussed are high-performance liquid chromatography, capillary electrophoretic chromatography, miceller electrokinetic chromatography, supercritical fluid chromatography, nanoliquid chromatography, and gas chromatography. Besides, the attempts have also been made to discuss the future challenges and prospectives of the enantiomeric resolution of multichiral racemates. [GRAPHICS] .

引用

页码：435 / 444

页数：10

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