Targeting natural killer cells to enhance vaccine responses

被引：37

作者：

Cox, Andrew ^{[1
,2
,3
]}

Cevik, Hilal ^{[1
,4
]}

Feldman, H. Alex ^{[1
,5
,6
]}

Canaday, Laura M. ^{[1
,5
]}

Lakes, Nora ^{[5
,6
]}

Waggoner, Stephen N. ^{[1
,3
,4
,5
,6
]}

机构：

[1] Cincinnati Childrens Hosp Med Ctr, Ctr Autoimmune Genom & Etiol, Cincinnati, OH 45229 USA

[2] Cincinnati Childrens Hosp Med Ctr, Div Infect Dis, Cincinnati, OH 45229 USA

[3] Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH 45221 USA

[4] Cincinnati Childrens Hosp Med Ctr, Mol & Dev Biol Grad Program, Cincinnati, OH 45229 USA

[5] Univ Cincinnati, Grad Program Immunol, Coll Med, Cincinnati, OH 45221 USA

[6] Univ Cincinnati, Med Sci Training Program, Coll Med, Cincinnati, OH 45221 USA

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2021年 / 42卷 / 09期

基金：

美国国家卫生研究院;

关键词：

SRC-FAMILY KINASES; NK CELLS; T-CELLS; INFLUENZA VACCINATION; HUMORAL IMMUNITY; HUMAN HEALTH; MEMORY; INFECTION; ACTIVATION; EXPRESSION;

D O I：

10.1016/j.tips.2021.06.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Vaccination serves as a cornerstone of global health. Successful prevention of infection or disease by vaccines is achieved through elicitation of pathogenspecific antibodies and long-lived memory T cells. However, several microbial threats to human health have proven refractory to past vaccine efforts. These shortcomings have been attributed to either inefficient triggering of memory T and B cell responses or to the unfulfilled need to stimulate non-conventional forms of immunological memory. Natural killer (NK) cells have recently emerged as both key regulators of vaccine-elicited T and B cell responses and as memory cells that contribute to pathogen control. We discuss potential methods to modulate these functions of NK cells to enhance vaccine success.

引用

页码：789 / 801

页数：13

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