Antioxidant and Anti-inflammatory Phenylpropanoid Derivatives from Calamus quiquesetinervius

被引：48

作者：

Chang, Chao-Lin ^{[1
,2
]}

Zhang, Li-Jie ^{[1
]}

Chen, Ru Yin ^{[3
]}

Kuo, Li-Ming Yang ^{[1
,4
]}

Huang, Jhih-Ping ^{[3
]}

Huang, Hui-Chi ^{[5
,6
]}

Lee, Kuo-Hsiung ^{[7
]}

Wu, Yang-Chang ^{[2
,8
]}

Kuo, Yao-Haur ^{[1
,5
,6
]}

机构：

[1] Natl Res Inst Chinese Med, Div Herbal Drugs & Nat Prod, Taipei 112, Taiwan

[2] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

[3] Food Ind Res & Dev Inst, Hsinchu 300, Taiwan

[4] Taipei Med Univ, Coll Pharm, Taipei 110, Taiwan

[5] China Med Univ, Dept Chinese Med Resources, Taichung 404, Taiwan

[6] China Med Univ, Grad Inst Integrated Med, Taichung 404, Taiwan

[7] Univ N Carolina, Nat Prod Res Labs, Eshelman Sch Pharm, Chapel Hill, NC 27599 USA

[8] China Med Univ, Coll Chinese Med, Taichung 404, Taiwan

来源：

JOURNAL OF NATURAL PRODUCTS | 2010年 / 73卷 / 09期

关键词：

PHENOLIC CONSTITUENTS; ULTRAWEAK CHEMILUMINESCENCE; SCAVENGING ABILITY; FOOD CONSTITUENTS; AQUEOUS EXTRACTS; GLYCOSIDES; NEOLIGNANS; ALCOHOL; LEAVES; BARK;

D O I：

10.1021/np100181c

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Eight new phenylpropanoid derivatives [quiquesetinerviusides A (1), B (2), C (3), D (4), and E (5), as well as quiquesetinerviusins A (6), B (7), and C (8)] and seven known compounds (8-15), were isolated from an EtOAc extract of Calamus quiquesetinervius stems. The structures of 1-8 were elucidated on the basis of 1D- and 2D-NMR spectroscopic data analysis. Bioassay results showed that 1-5 possess weak DPPH (2,2-diphenyl-1-picrylhydrazyl) scavenging activity, but potent (center dot)OH radical scavenging activity (IC(50) 3.6-8.4 mu M). Of the tested isolates, compounds 4-6 and 9 showed potent inhibition (IC(50) 9.2-29.5 mu M) of LPS-stimulated NO production when compared with a positive control substance, quercetin (IC(50) 34.5 mu M).

引用

页码：1482 / 1488

页数：7

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