Zika Vaccine Development: Current Status

被引：61
作者：
Poland, Gregory A. [1 ,2 ]
Ovsyannikova, Inna G. [1 ,2 ]
Kennedy, Richard B. [1 ,2 ]
机构：
[1] Mayo Clin, Vaccine Res Grp, 200 First St SW, Rochester, MN 55905 USA
[2] Mayo Clin, Div Gen Internal Med, Rochester, MN USA
来源：
MAYO CLINIC PROCEEDINGS | 2019年 / 94卷 / 12期
关键词：
VIRUS-INFECTION; ANIMAL-MODELS; DNA VACCINE; DENGUE; RESPONSES; IMMUNOGENICITY; TRANSMISSION; AMERICA; AFRICAN; DISEASE;
D O I：
10.1016/j.mayocp.2019.05.016
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Zika virus outbreaks have been explosive and unpredictable and have led to significant adverse health effectsdas well as considerable public anxiety. Significant scientific work has resulted in multiple candidate vaccines that are now undergoing further clinical development, with several vaccines now in phase 2 clinical trials. In this review, we survey current vaccine efforts, preclinical and clinical results, and ethical and other concerns that directly bear on vaccine development. It is clear that the world needs safe and effective vaccines to protect against Zika virus infection. Whether such vaccines can be developed through to licensure and public availability absent significant financial investment by countries, and other barriers discussed within this article, remains uncertain. (C) 2019 Mayo Foundation for Medical Education and Research
引用
收藏
页码：2572 / 2586
页数：15
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