Antileishmanial amides and lignans from Piper cubeba and Piper retrofractum

被引：73

作者：

Bodiwala, Hardik S.

Singh, Gaganmeet

Singh, Ranvir

Dey, Chinmoy Sankar

Sharma, Shyam Sundar

Bhutani, Kamlesh Kumar

Singh, Inder Pal

机构：

[1] NIPER, Dept Nat Prod, Nagar 160062, Punjab, India

[2] NIPER, Dept Biotechnol, Nagar 160062, Punjab, India

[3] NIPER, Dept Pharmacol & Toxicol, Nagar 160062, Punjab, India

来源：

JOURNAL OF NATURAL MEDICINES | 2007年 / 61卷 / 04期

关键词：

Piper cubeba; Piper retrofractum; antileishmanial; promastigotes; lignan; amide;

D O I：

10.1007/s11418-007-0159-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The n-hexane, ethyl acetate, methanol, and acetone extracts of Piper cubeba Linn. and P. retrofractum Vahl. (Piperaceae) were evaluated in vitro against promastigotes of Leishmania donovani, and all exhibited significant in vitro activity at 100 mu g/ml. Two lignans, cubebin and hinokinin, were isolated from the hexane extract of P. cubeba; and one bis-epoxy lignan, (-)-sesamin, and two amides, pellitorine and piplartine, were isolated from the hexane and methanol extracts of P. retrofractum. Cubebin and piplartine showed significant antileishmanial activity in vitro at 100 mu M and were further tested in vivo in a hamster model of visceral leishmaniasis. Piplartine showed activity at 30 mg/kg dose. This is the first report of antileishmanial activity of these two plants and their isolated constituents.

引用

收藏

页码：418 / 421

页数：4

相关论文

共 50 条

[31] Cubeb (Piper cubeba L.): nutritional value, phytochemical profiling and dermacosmeceutical properties [J].

Drissi, Badr Eddine ;

Mahdi, Ismail ;

Ortaakarsu, Ahmet Bugra ;

Abdelfattah, Mohamed A. O. ;

Bakrim, Widad Ben ;

Khatib, Sohaib ;

Mahmoud, Mona F. ;

Bouissane, Latifa ;

Sobeh, Mansour .

FRONTIERS IN NUTRITION, 2024, 11

[32] Effect of leaf growth on the taste and aroma functions and antioxidant characteristics of hihatsumodoki (Piper retrofractum Vhal) leaf [J].

Takahashi, Makoto ;

Oe, Moena ;

Arakaki, Mika ;

Wada, Koji .

JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION, 2020, 14 (02) :1002-1011

[33] Green synthesis and characterization of copper nanoparticles using Piper retrofractum Vahl extract as bioreductor and capping agent [J].

Amaliyah, Suci ;

Pangesti, Dwika Putri ;

Masruri, Musruri ;

Sabarudin, Akhmad ;

Sumitro, Sutiman Bambang .

HELIYON, 2020, 6 (08)

[34] New enantiomeric lignans and new meroterpenoids with nitric oxide release inhibitory activity from Piper puberulum [J].

Zheng, Yuan-kun ;

Wang, Ya-qi ;

Su, Bao-jun ;

Wang, Heng-shan ;

Liao, Hai-bing ;

Liang, Dong .

BIOORGANIC CHEMISTRY, 2022, 119

[35] Analysis of piperine content in cabe jawa extracts (Piper retrofractum Vahl) using UV spectrophotometry and HPLC [J].

Cahyono, Bambang ;

Hasanah, Eli Fatihatul ;

Judiono ;

Suzery, Meiny ;

Widayat .

13TH JOINT CONFERENCE ON CHEMISTRY (13TH JCC), 2019, 509

[36] Antibacterial activity of (-)-cubebin isolated from Piper cubeba and its semisynthetic derivatives against microorganisms that cause endodontic infections [J].

Rezende, Karen C. S. ;

Lucarini, Rodrigo ;

Simaro, Guilherme V. ;

Pauletti, Patricia M. ;

Januario, Ana H. ;

Esperandim, Viviane R. ;

Martins, Carlos H. G. ;

Silva, Mislaine A. ;

Cunha, Wilson R. ;

Bastos, Jairo K. ;

Silva, Mrcio L. A. E. .

REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, 2016, 26 (03) :296-303

[37] Evaluation of Piper cubeba extract, (-)-cubebin and its semi-synthetic derivatives against oral pathogens [J].

Silva, M. L. A. ;

Coimbra, H. S. ;

Pereira, A. C. ;

Almeida, V. A. ;

Lima, T. C. ;

Costa, E. S. ;

Vinholis, A. H. C. ;

Royo, V. A. ;

Silva, R. ;

Filho, A. A. S. ;

Cunha, W. R. ;

Furtado, N. A. J. C. ;

Martins, Carlos H. G. ;

Carvalho, T. C. ;

Bastos, J. K. .

PHYTOTHERAPY RESEARCH, 2007, 21 (05) :420-422

[38] Chemical Constituents, Antioxidative and Antimicrobial Activities of Essential Oil and Oleoresin of Tailed Pepper (Piper Cubeba L) [J].

Singh, Gurdip ;

Marimuthu, Palanisamy ;

de Heluani, Carola S. ;

Catalan, Cesar A. N. .

INTERNATIONAL JOURNAL OF FOOD ENGINEERING, 2007, 3 (06)

[39] In vivo anthelmintic activity of hydroethanolic extract of Piper cubeba fruits in sheep naturally infected with gastrointestinal nematodes [J].

Sanchez, Clara de Araujo ;

Goncalves, Juliana Alencar ;

Andrade e Silva, Marcio Luis ;

Rodrigues, Maria Gabriela Fontanetti ;

Santos, Fernanda Amorim ;

de Laurentiz, Rosangela da Silva ;

de Soutello, Ricardo Velludo Gomes .

VETERINARY PARASITOLOGY, 2025, 333

[40] Flavor characteristics and antioxidant capacities of hihatsumodoki (Piper retrofractum Vahl) fresh fruit at three edible maturity stages [J].

Takahashi, Makoto ;

Hirose, Naoto ;

Ohno, Suguru ;

Arakaki, Mika ;

Wada, Koji .

JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE, 2018, 55 (04) :1295-1305

← 1 2 3 4 5 →