Cancer Evolution Constrained by the Immune Microenvironment

被引：361

作者：

McGranahan, Nicholas ^{[1
]}

Swanton, Charles ^{[1
,2
]}

机构：

[1] UCL, Canc Inst, Canc Res UK Lung Canc Ctr Excellence, Paul OGorman Bldg,72 Huntley St, London WC1E 6BT, England

[2] Francis Crick Inst, Translat Canc Therapeut Lab, 1 Midland Rd, London NW1 1AT, England

来源：

CELL | 2017年 / 170卷 / 05期

基金：

英国医学研究理事会;

关键词：

CHECKPOINT BLOCKADE;

D O I：

10.1016/j.cell.2017.08.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tumor development is a Darwinian evolutionary process, involving the interplay between cancer subclones and the local immune microenvironment. These complex interactions are highlighted in this issue of Cell by the results from Jimenez-Sanchez et al. of a deep analysis of one patient with advanced serous carcinoma of the ovary.

引用

页码：825 / 827

页数：4

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