Ten daily fractions for partial breast irradiation. Long-term results of a prospective phase II trial

被引：10

作者：

Vinante, Lorenzo ^{[1
]}

Avanzo, Michele ^{[2
]}

Furlan, Carlo ^{[1
,3
]}

Fiorica, Francesco ^{[4
]}

Perin, Tiziana ^{[5
]}

Militello, Loredana ^{[6
]}

Spazzapan, Simon ^{[6
]}

Berretta, Massimiliano ^{[6
]}

Jena, Rajesh ^{[7
]}

Stancanello, Joseph ^{[8
]}

Piccoli, Erica ^{[9
]}

Mileto, Mario ^{[9
]}

Micheli, Elvia ^{[10
]}

Roncadin, Mario ^{[1
]}

Massarut, Samuele ^{[9
]}

Trovo, Marco ^{[1
,11
]}

机构：

[1] IRCCS, Dept Radiat Oncol, Ctr Riferimento Oncol Aviano CRO, Aviano, Italy

[2] IRCCS, Ctr Riferimento Oncol Aviano CRO, Div Med Phys, Aviano, Italy

[3] Belluno Gen Hosp, Dept Radiat Oncol, Belluno, Italy

[4] Univ Hosp S Anna, Dept Radiat Oncol, Ferrara, Italy

[5] IRCCS, Ctr Riferimento Oncol Aviano CRO, Dept Pathol, Aviano, Italy

[6] IRCCS, Ctr Riferimento Oncol Aviano CRO, Dept Med Oncol, Aviano, Italy

[7] Cambridge Univ Hosp NHS Fdn Trust, Oncol Ctr, Cambridge, England

[8] IRCCS, Ctr Riferimento Oncol Aviano CRO, Aviano, Italy

[9] IRCCS, Ctr Riferimento Oncol Aviano CRO, Dept Oncol & Surg, Breast Surg Unit, Aviano, Italy

[10] Pordenone Gen Hosp, Dept Gen Surg, Pordenone, Italy

[11] Udine Gen Hosp, Dept Radiat Oncol, Udine, Italy

来源：

BREAST JOURNAL | 2019年 / 25卷 / 02期

关键词：

breast cancer; clinical outcome; hypofractionation; partial breast irradiation; toxicity; MODULATED RADIATION-THERAPY; CONSERVING SURGERY; LUMPECTOMY CAVITY; FOLLOW-UP; RTOG; 0319; TOXICITY; CANCER; RADIOTHERAPY; COSMESIS; SURVIVAL;

D O I：

10.1111/tbj.13195

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Partial breast irradiation (PBI) is an effective adjuvant treatment after breast conservative surgery for selected early-stage breast cancer patients. However, the best fractionation scheme is not well defined. Hereby, we report the 5-year clinical outcome and toxicity of a phase II prospective study of a novel regimen to deliver PBI, which consists in 40 Gy delivered in 10 daily fractions. Patients with early-stage (pT1-pT2, pN0-pN1a, M0) invasive breast cancer were enrolled after conservative surgery. The minimum age at diagnosis was 60 years old. PBI was delivered with 3D-conformal radiotherapy technique with a total dose of 40 Gy, fractionated in 10 daily fractions (4 Gy/fraction). Eighty patients were enrolled. The median follow-up was 67 months. Five-year local control (LC), disease-free survival (DFS), and overall survival (OS) were 95%, 91%, and 96%, respectively. Grade I and II subcutaneous fibrosis were documented in 23% and 5% of cases. No grade III late toxicity was observed. PBI delivered in 40 Gy in 10 daily fractions provided good clinical results and was a valid radiotherapy option for early-stage breast cancer patients.

引用

页码：243 / 249

页数：7

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