CYP gene expressions in obesity-associated metabolic syndrome

被引：12
|
作者：
Tabur, Suzan [1 ]
Oztuzcu, Serdar [2 ]
Oguz, Elif [3 ]
Demiryurek, Seniz [4 ]
Dagli, Hasan [2 ]
Alasehirli, Belgin [5 ]
Ozkaya, Mesut [1 ]
Demiryurek, Abdullah T. [5 ]
机构：
[1] Gaziantep Univ, Div Endocrinol, Dept Internal Med, Fac Med, TR-27310 Gaziantep, Turkey
[2] Gaziantep Univ, Dept Med Biol, Fac Med, Gaziantep, Turkey
[3] Harran Univ, Dept Med Pharmacol, Fac Med, Sanliurfa, Turkey
[4] Gaziantep Univ, Fac Med, Dept Physiol, Gaziantep, Turkey
[5] Gaziantep Univ, Dept Med Pharmacol, Fac Med, Gaziantep, Turkey
来源：
OBESITY RESEARCH & CLINICAL PRACTICE | 2016年 / 10卷 / 06期
关键词：
Cytochrome P450; Gene expression; Metabolic syndrome; Obesity; Polymerase chain reaction; BLOOD-PRESSURE REGULATION; CYTOCHROME-P450; 3A; 20-HETE;
D O I：
10.1016/j.orcp.2016.03.001
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Purpose: The contribution of cytochrome P450 (CYP) gene expressions in metabolic syndrome (MetS) has not been elucidated, and was the aim of this study. Methods: A total of 51 MetS patients and 41 healthy controls with similar age and sex were included to this study. mRNA from blood samples was extracted, and real-time polymerase chain reaction was performed for gene expressions using a dynamic array system. Results: We observed marked suppressions in CYP2A6 (p = 0.0123), CYP4F2 (p = 0.0005), CYP3A5 (p = 0.0003), and CYP17A1 (p < 0.0001) gene expressions in MetS patients. Conclusions: This is the first study to provide evidence that depressed expressions of CYP2A6, CYP4F2, CYP3A5, and CYP17A1 genes may play a role in MetS. (C) 2016 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：719 / 723
页数：5
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