CYP gene expressions in obesity-associated metabolic syndrome

被引：12

作者：

Tabur, Suzan ^{[1
]}

Oztuzcu, Serdar ^{[2
]}

Oguz, Elif ^{[3
]}

Demiryurek, Seniz ^{[4
]}

Dagli, Hasan ^{[2
]}

Alasehirli, Belgin ^{[5
]}

Ozkaya, Mesut ^{[1
]}

Demiryurek, Abdullah T. ^{[5
]}

机构：

[1] Gaziantep Univ, Div Endocrinol, Dept Internal Med, Fac Med, TR-27310 Gaziantep, Turkey

[2] Gaziantep Univ, Dept Med Biol, Fac Med, Gaziantep, Turkey

[3] Harran Univ, Dept Med Pharmacol, Fac Med, Sanliurfa, Turkey

[4] Gaziantep Univ, Fac Med, Dept Physiol, Gaziantep, Turkey

[5] Gaziantep Univ, Dept Med Pharmacol, Fac Med, Gaziantep, Turkey

来源：

OBESITY RESEARCH & CLINICAL PRACTICE | 2016年 / 10卷 / 06期

关键词：

Cytochrome P450; Gene expression; Metabolic syndrome; Obesity; Polymerase chain reaction; BLOOD-PRESSURE REGULATION; CYTOCHROME-P450; 3A; 20-HETE;

D O I：

10.1016/j.orcp.2016.03.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose: The contribution of cytochrome P450 (CYP) gene expressions in metabolic syndrome (MetS) has not been elucidated, and was the aim of this study. Methods: A total of 51 MetS patients and 41 healthy controls with similar age and sex were included to this study. mRNA from blood samples was extracted, and real-time polymerase chain reaction was performed for gene expressions using a dynamic array system. Results: We observed marked suppressions in CYP2A6 (p = 0.0123), CYP4F2 (p = 0.0005), CYP3A5 (p = 0.0003), and CYP17A1 (p < 0.0001) gene expressions in MetS patients. Conclusions: This is the first study to provide evidence that depressed expressions of CYP2A6, CYP4F2, CYP3A5, and CYP17A1 genes may play a role in MetS. (C) 2016 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.

引用

页码：719 / 723

页数：5

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