Fetal Alcohol Spectrum Disorders-a Case-Control Study from India

被引：8
作者：
Nayak, Raghavendra [1 ]
Murthy, Pratima [2 ]
Girimaji, Satish [2 ]
Navaneetham, Jamuna [3 ]
机构：
[1] KLE Univ, Dept Psychiat, Jawaharlal Nehru Med Coll, Belgaum 590010, Karnataka, India
[2] Natl Inst Mental Hlth & Neurosci NIMHANS, Dept Psychiat, Bangalore, Karnataka, India
[3] Natl Inst Mental Hlth & Neurosci NIMHANS, Dept Clin Psychol, Bangalore, Karnataka, India
来源：
JOURNAL OF TROPICAL PEDIATRICS | 2012年 / 58卷 / 01期
关键词：
prenatal alcohol exposure; fetal alcohol spectrum disorders; fetal alcohol syndrome; intellectual dysfunction; behavioral problems; DEFICIT HYPERACTIVITY DISORDER; MATERNAL SMOKING; FACIAL PHENOTYPE; CHILDREN; INDIVIDUALS; PREGNANCY; DIAGNOSIS; EXPOSURE;
D O I：
10.1093/tropej/fmr015
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Background: Maternal alcohol abuse during pregnancy can lead to fetal neurotoxicity and fetal alcohol spectrum disorder (FASD). Aims: To compare the clinical features and neurobehavioral profiles of children exposed to alcohol during pregnancy with controls. Methodology: Children exposed to alcohol in utero (n = 26) and 27-years age- and sex-matched controls were compared on FAS facial features, minor physical anomalies (MPAs), anthropometric measures, behavioral problems and intellectual functioning. Results: MPAs were more common in cases (p = 0.001). Among FAS facial features, only philtrum smoothness varied significantly between the groups (p = 0.001). Behavioral problems (on Childhood Behavior Check List) were more pronounced (p = 0.001) and intellectual functioning significantly poorer in cases (p = 0.001) compared to controls. Conclusions: Children prenatally exposed to alcohol manifest several neurobehavioral problems compared to controls. Underlying malnutrition may have altered some of the clinical findings.
引用
收藏
页码：19 / 24
页数：6
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