Survivin - The inconvenient IAP

被引：125

作者：

Altieri, Dario C. ^{[1
]}

机构：

[1] Wistar Inst Anat & Biol, Tumor Microenvironm & Metastasis Program, Philadelphia, PA 19104 USA

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2015年 / 39卷

基金：

美国国家卫生研究院;

关键词：

Survivin; IAP; Cell division; Apoptosis; Cancer; Mitotic catastrophe; CHROMOSOMAL PASSENGER COMPLEX; EMBRYONIC STEM-CELLS; PHOSPHORYLATED HISTONE H3; WILD-TYPE P53; AURORA-B; IN-VIVO; MITOTIC CATASTROPHE; INNER CENTROMERE; BREAST-CANCER; MICROTUBULE DYNAMICS;

D O I：

10.1016/j.semcdb.2014.12.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Although technically a member of the Inhibitor of Apoptosis (IAP) gene family, survivin has consistently defied assumptions, refuted predictions and challenged paradigms. Despite its more than 5500 citations currently in Medline, the biology of survivin has remained fascinatingly complex, its exploitation in human disease, most notably cancer, tantalizing, and its regulation of cellular homeostasis unexpectedly far-reaching. An inconvenient outsider that resists schemes and dogmas, survivin continues to hold great promise to unlock fundamental circuitries of cellular functions in health and disease. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：91 / 96

页数：6

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