Uses of 1-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]-thiophen-2-yl)-3-dodecanoylthiourea as a Building Block in the Synthesis of Fused Pyrimidine and Thiazine Systems

被引：15

作者：

Hemdan, Magdy Mohamed ^{[1
]}

Abd El-Mawgoude, Heba Kamal ^{[2
]}

机构：

[1] Ain Shams Univ, Fac Sci, Dept Chem, Cairo 11566, Egypt

[2] Ain Shams Univ Heliopolis, Fac Women, Dept Chem, Cairo 11767, Egypt

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2015年 / 63卷 / 06期

关键词：

lauroyl isothiocyanate; pyrimidine derivative; fused system; 2-amino-4,5,6,7-tetrahydrobenzo[b]-thiophene-3-carbonitrile; BIOLOGICAL-ACTIVITY; FACILE SYNTHESIS; INHIBITORS; NUCLEOSIDES; ANTICANCER;

D O I：

10.1248/cpb.c15-00047

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The reaction of lauroyl isothiocyanate and 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile was used to synthesize the title compound 2. Compound 2 could serve as the main building block in the synthesis of many target heterocyclic systems. Various fused pyrimidines were synthesized in the reactions of compound 2 with sodium ethoxide, hydrazine hydrate, phenyl hydrazine, ethyl carbazate, thiourea, and/or 2-aminothiophenol. The structures of the synthesized compounds were confirmed by microanalytical and spectral data.

引用

页码：450 / 456

页数：7

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