Emerging toxin A-B plus variant strain of Clostridium difficile responsible for pseudomembranous colitis at a tertiary care hospital in Korea

被引：54

作者：

Shin, Bo-Moon ^{[1
,3
]}

Kuak, Eun Young ^{[1
]}

Yoo, Soo Jin ^{[1
]}

Shin, Won Chang ^{[2
]}

Yoo, Hyeon Mi ^{[3
]}

机构：

[1] Inje Univ, Sch Med, Sanggye Paik Hosp, Dept Lab Med, Seoul 139707, South Korea

[2] Inje Univ, Sanggye Paik Hosp, Internal Med, Seoul 139707, South Korea

[3] Inje Univ, Sanggye Paik Hosp, Off Infect Control, Seoul 139707, South Korea

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2008年 / 60卷 / 04期

关键词：

Clostridium difficile; tcdA; tcdB; PCR ribotyping; pseudomembranous colitis;

D O I：

10.1016/j.diagmicrobio.2007.10.022

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Sixty percent to 80% of Clostridium difficile isolates in Korea have been reported to be toxigenic. However, over I year, we encountered a high number of tcdA-tcB+ strains associated with pseudomembranous colitis (PMC). C. difficile was isolated from 224 of 471 specimens (47.6%) from 371 patients. A subset of the culture-positive specimens (n = 106), containing no duplicate cases, was randomly selected for tcdA and tcdB polymerase chain reaction (PCR) assays. PCR results showed that tcdA+tcdB+ and tcdA-tcdB+ strains accounted for 39.6% (42/106) and 50.9% (54/106), respectively. Endoscopy, performed on 55/106 patients, revealed 29 with PMC, 5 with colitis, 14 with other colon diseases, and 7 normal cases. Among the 29 PMC cases, 21 (72.4%) were associated with tcdA-tcdB+ strains (P = 0.0016). These results revealed the possible emergence of tcdA-tcdB+ C. difficile strains in Korea, and these variant strains could evoke a higher rate of PMC than tcdA+tcdB+ strains. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：333 / 337

页数：5

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