Resveratrol affects DNA damage induced by ionizing radiation in human lymphocytes in vitro

被引：15

作者：

Basso, Emiliano ^{[1
]}

Regazzo, Giulia ^{[1
]}

Fiore, Mario ^{[2
]}

Palma, Valentina ^{[3
]}

Traversi, Gianandrea ^{[1
]}

Testa, Antonella ^{[3
]}

Degrassi, Francesca ^{[2
]}

Cozzi, Renata ^{[1
]}

机构：

[1] Univ Rome Tre, Dipartimento Sci, Viale G Marconi 446, I-00146 Rome, Italy

[2] CNR, Ist Biol Mol & Patol, Rome, Italy

[3] ENEA, Sez Tossicol & Sci Biomed, Casaccia Roma, Italy

来源：

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS | 2016年 / 806卷

关键词：

Ionizing radiations resveratrol dicentrics; YH2AX DNA damage repair HDAC activity; HISTONE DEACETYLASE INHIBITORS; INDUCED APOPTOSIS; CHROMOSOME SEGREGATION; TOPOISOMERASE-II; CLINICAL-TRIALS; CELL LINES; REPAIR; DISEASE; RADIOSENSITIVITY; CARCINOGENESIS;

D O I：

10.1016/j.mrgentox.2016.07.005

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Resveratrol (3,4',5-trihydroxystilbene; RSV) acts on cancer cells in several ways, inducing cell cycle delay and apoptotic death, and enhancing ionizing radiation (IR)-mediated responses. However, fewer studies have examined RSV effects on normal cells. We have treated human lymphocytes in vitro with RSV, either alone or combined with IR, to evaluate its potential use as a radioprotector. We measured the effects of RSV on induction of DNA damage, repair kinetics, and modulation of histone deacetylase activity. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：40 / 46

页数：7

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