CuO/Cu2O nanowire array photoelectrochemical biosensor for ultrasensitive detection of tyrosinase

被引：37

作者：

Guo, Xiaoxi ^{[1
]}

Wu, Jinghua ^{[1
]}

Xia, Lian ^{[1
]}

Xiang, Meihao ^{[1
]}

Qu, Fengli ^{[1
]}

Li, Jinghong ^{[2
]}

机构：

[1] Qufu Normal Univ, Coll Chem & Chem Engn, Qufu 273165, Shandong, Peoples R China

[2] Tsinghua Univ, Dept Chem, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing 100084, Peoples R China

来源：

SCIENCE CHINA-CHEMISTRY | 2020年 / 63卷 / 07期

基金：

中国国家自然科学基金;

关键词：

tyrosinase; CuO; Cu2O nanowire; photoelectrochemical biosensor; chitosan modified electrode; quinones; MUTATIONS; CHEMISTRY; DOPAMINE; CHITOSAN;

D O I：

10.1007/s11426-020-9717-8

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Photoelectrochemical (PEC) biosensors have shown great promise in bioanalysis and diagnostic applications in recent years. In this work, the CuO/Cu2O nanowire array (CuO/Cu2O Nanowire) supported on copper foam was prepared as a photocathode for detection of tyrosinase though quinone-chitosan conjugation chemistry method. The in-situ generated quinones that were the catalytic product of tyrosinase acted as electron acceptors, which were captured by the chitosan deposited on the surface of the electrode. Direct immobilization of electron acceptor on the electrode surface improved the photocurrent conversion efficiency and thus sensitivity. The as-prepared biosensor can realize a rapid response in a wide linear range of 0.05 U/mL to 10 U/mL with the detection limit as low as 0.016 U/mL of tyrosinase. The current work provides a new perspective to design and develop highly sensitive and selective PEC biosensor.

引用

页码：1012 / 1018

页数：7

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