Patterns of postoperative radiotherapy for head and neck cancer in Italy: a prospective, observational study by the head and neck group of the Italian Association for Radiation Oncology (AIRO)

被引：0

作者：

Palazzi, Mauro ^{[1
]}

Alterio, Daniela ^{[2
]}

Tonoli, Sandro ^{[3
]}

Caspiani, Orietta ^{[4
]}

Bolner, Andrea ^{[5
]}

Colombo, Sara ^{[6
]}

Dall'Oglio, Stefano ^{[7
]}

Lastrucci, Luciana ^{[8
]}

Bunkheila, Feisal ^{[9
]}

Cianciulli, Michele ^{[10
]}

Taglianti, Riccardo Vigna ^{[11
]}

Cante, Domenico ^{[12
]}

Merlotti, Anna ^{[13
]}

Bianchi, Ernestina ^{[14
]}

Rampino, Monica ^{[15
]}

Podhradska, Andrea ^{[16
]}

Fontana, Antonella ^{[17
]}

Paiar, Fabiola ^{[18
]}

Micciche, Francesco ^{[19
]}

Manzo, Roberto ^{[20
]}

Ursino, Stefano ^{[21
]}

Bruschieri, Lorenza ^{[22
]}

Bacigalupo, Almalina ^{[23
]}

Iannone, Tiziana ^{[24
]}

Barca, Raffaella ^{[25
]}

Tomatis, Stefano ^{[26
]}

机构：

[1] Osped Niguarda Ca Granda, Radiotherapy Unit, I-20100 Milan, Italy

[2] European Inst Oncol, Radiotherapy Unit, Milan, Italy

[3] Univ Hosp, Ist Radio O Alberti, Radiotherapy Unit, Brescia, Italy

[4] Isola Tiberina Fatebenefratelli Hosp, Radiotherapy Unit, Rome, Italy

[5] Santa Chiara Hosp, Radiotherapy Unit, Trento, Italy

[6] Policlin S Matteo Fdn, Radiotherapy Unit, Pavia, Italy

[7] Univ Hosp, Radiotherapy Unit, Verona, Italy

[8] S Donato USL8 Hosp, Radiotherapy Unit, Arezzo, Italy

[9] Policlin S Orsola Hosp, Radiotherapy Unit, Bologna, Italy

[10] San Camillo Hosp, Radiotherapy Unit, Rome, Italy

[11] S Croce & Carle Hosp, Radiotherapy Unit, Cuneo, Italy

[12] ASL TO4 Hosp, Radiotherapy Unit, Ivrea, Italy

[13] Osped Circolo, Radiotherapy Unit, Busto Arsizio, Italy

[14] St Anna Hosp, Radiotherapy Unit, Como, Italy

[15] S Giovanni Battista Le Molinette Univ Hosp, Radiotherapy Unit, Turin, Italy

[16] S Gerardo Hosp, Radiotherapy Unit, Monza, Italy

[17] S Maria Goretti Hosp, Radiotherapy Unit, Latina, Italy

[18] Policlin Careggi Univ Hosp, Radiotherapy Unit, Florence, Italy

[19] Policlin Gemelli Univ Hosp, Radiotherapy Unit, Rome, Italy

[20] C Ascalesi Hosp, Radiotherapy Unit, Naples, Italy

[21] Arcispedale S Anna Hosp, Radiotherapy Unit, Ferrara, Italy

[22] Treviglio Caravaggio Hosp, Radiotherapy Unit, Treviglio, Italy

[23] Natl Canc Res Inst, Radiotherapy Unit, Genoa, Italy

[24] San Martino Hosp, Radiotherapy Unit, Belluno, Italy

[25] Ecomedica, Radiotherapy Unit, Empoli, Italy

[26] Ist Nazl Tumori, Med Phys Unit, Radiotherapy Unit, I-20133 Milan, Italy

来源：

TUMORI | 2011年 / 97卷 / 02期

关键词：

head and neck cancer; postoperative radiotherapy; observational study; SQUAMOUS-CELL CARCINOMA; RANDOMIZED TRIAL; THERAPY; RTOG; MANAGEMENT; SURGERY;

D O I：

10.1177/030089161109700207

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aims and background. Our previous survey showed that the patterns of postoperative radiotherapy (PORT) for head and neck cancer (HNC) in Italy might be suboptimal. A prospective observational study was therefore designed to evaluate this issue in greater detail. Methods. All radiotherapy centers involved in the HNC Working Group of the Italian Radiation Oncology Association were asked to enter into the study all patients treated with PORT during a 6-month period. Results. A total of 200 patients were accrued by 24 centers from December 2008 to May 2009. Larynx (38%) and oral cavity (34%) were the most common primary sites. The median time between surgery and the start of radiotherapy was 69 days (range, 25-215 days). Seventy-nine percent of cases with no evidence of risk factors for local recurrence were treated with high-dose radiotherapy to the primary site. In about 75% of cases the pN0 neck was included in the target volume. Concomitant chemotherapy was delivered to about 60% of patients with major risk factors and 21% of patients with no risk factors. Conclusions. Three issues emerged from our study as potential targets for future investigations: the impact on clinical outcome of the interval between surgery and the start of PORT; factors driving radiation oncologists to overtreat volumes at low risk of recurrence; and problems associated with the delivery of concomitant chemotherapy.

引用

页码：170 / 176

页数：7

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