Preserving fertility: using cyclophosphamide and other cytotoxics in young people

被引：7

作者：

Ledingham, David ^{[1
]}

Plant, Michael ^{[2
]}

Mustafa, Fayez ^{[3
]}

Patil, Bhimanagouda ^{[1
]}

机构：

[1] James Cook Univ Hosp, Neurol, Middlesbrough TS4 3BW, Cleveland, England

[2] James Cook Univ Hosp, Rheumatol, Middlesbrough, Cleveland, England

[3] James Cook Univ Hosp, Reprod Med, Middlesbrough, Cleveland, England

来源：

PRACTICAL NEUROLOGY | 2020年 / 20卷 / 02期

关键词：

Cyclophosphamide; Fertility; Cytotoxic; PRESERVATION;

D O I：

10.1136/practneurol-2019-002247

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Cytotoxic agents such as cyclophosphamide are infrequently used in neurological practice. When they are, it is commonly in critically ill patients or in those with refractory inflammatory disorders. Cyclophosphamide in particular has a well-recognised negative impact on both female and male long-term fertility. This article summarises the data with regards the impact of cytotoxics on long-term fertility and describes the current options to preserve fertility in these patients. We hope this will provide neurologists with a useful aid for counselling patients for whom they are considering these treatments.

引用

页码：148 / 153

页数：6

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