Childhood methylphenidate treatment of ADHD and response to affective stimuli

被引:35
作者
Schlochtermeier, Lorna [1 ]
Stoy, Meline [1 ]
Schlagenhauf, Florian [1 ]
Wrase, Jana [1 ]
Park, Soyoung Q. [2 ]
Friedel, Eva [1 ]
Huss, Michael [3 ]
Lehmkuhl, Ulrike [4 ]
Heinz, Andreas [1 ]
Stroehle, Andreas [1 ]
机构
[1] Charite, Dept Psychiat & Psychotherapy, D-10117 Berlin, Germany
[2] Free Univ Berlin, Dept Emot Psychol & Affect Neurosci, D-1000 Berlin, Germany
[3] Johannes Gutenberg Univ Mainz, Dept Child & Adolescent Psychiat & Psychotherapy, Mainz, Germany
[4] Charite, Dept Child & Adolescent Psychiat & Psychotherapy, D-10117 Berlin, Germany
关键词
Attention-deficit/hyperactivity disorder (ADHD); Emotional pictures; FMRI; Ventral striatum; Subgenual cingulate; Methylphenidate; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DEFICIT HYPERACTIVITY DISORDER; SUBSTANCE USE DISORDERS; REWARD ANTICIPATION; FOLLOW-UP; ADULTS; CHILDREN; EMOTION; RISK; HYPORESPONSIVENESS;
D O I
10.1016/j.euroneuro.2010.05.001
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Neural correlates of emotional dysregulation in attention-deficit/hyperactivity disorder (ADHD) and persisting influence of Methylphenidate (MPH) still remain insufficiently understood. Decreased activation in the subgenual cingulate and the ventral striatum were found during the perception of positive and negative affective pictures in drug-naive males with ADHD during childhood (n=10). Males with ADHD during childhood treated with MPH (n=10) did not show any significant differences compared to healthy controls (n=10). Further prospective studies need to clarify direct and indirect mechanisms of MPH treatment that may contribute to emotional processing, which is dysfunctional in males without pharmacological treatment in childhood. (C) 2010 Elsevier B.V. and ECNP. All rights reserved.
引用
收藏
页码:646 / 654
页数:9
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