Changes of chromosome aberration rate and micronucleus frequency along with accumulated doses in continuously irradiated mice with a low dose rate of γ-rays

被引：0

作者：

Tanaka, K ^{[1
]}

Kohda, A ^{[1
]}

Ichinohe, K ^{[1
]}

Matsumoto, T ^{[1
]}

机构：

[1] IES, Dept Radiobiol, Rokkasho, Japan

来源：

HIGH LEVELS OF NATURAL RADIATION AND RADON AREAS: RADIATION DOSE AND HEALTH EFFECTS | 2005年 / 1276卷

关键词：

low dose rate; gamma rays; chromosome aberrations; micronucleus; genetic instability;

D O I：

10.1016/j.ics.2004.12.005

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Chronological changes of chromosome aberration rates (CAs) along with accumulated doses in exposed mice with a low dose rate of gamma-ray were studied. CA and micronuclei in spleen cells were observed serially in mice continuously irradiated at 20 mGy/day up to 400 days for 8 Gy. Unstable types of CA rates were rapidly increased at 1 Gy, while micronucleus incidence increased from 5 Gy. Over these doses, their increase rates were saturated. FISH analysis in spleen cells of mice exposed to 8 Gy had higher incidence of monosomy and trisomy than in non-exposed mice. The number of cells with 2-3 micronuclei out of 10,000 spleen cells is also higher in 5 to 8 Gy-exposed mice. These results indicate that prolonged gamma-ray-iffadiation at low dose rates of 20 mGy/day induces a delayed chromosome instability in mice. (c) 2004 Published by Elsevier B.V.

引用

页码：177 / 178

页数：2

共 2 条

[1] Dose and dose-rate effects of low-dose ionizing radiation on activation of Trp53 in immortalized murine cells [J].