Antipsychotic-induced extrapyramidal side effects: A systematic review and meta-analysis of observational studies

被引:32
作者
Ali, Tilahun [1 ]
Sisay, Mekonnen [2 ]
Tariku, Mandaras [1 ]
Mekuria, Abraham Nigussie [2 ]
Desalew, Assefa [3 ]
机构
[1] Haramaya Univ, Coll Hlth & Med Sci, Sch Nursing & Midwifery, Dept Psychiat, Harar, Ethiopia
[2] Haramaya Univ, Coll Hlth & Med Sci, Sch Pharm, Dept Pharmacol & Toxicol, Harar, Ethiopia
[3] Haramaya Univ, Coll Hlth & Med Sci, Sch Nursing & Midwifery, Harar, Ethiopia
来源
PLOS ONE | 2021年 / 16卷 / 09期
关键词
INDUCED MOVEMENT-DISORDERS; TARDIVE-DYSKINESIA; RATING-SCALE; 2ND-GENERATION ANTIPSYCHOTICS; PREVALENCE; SCHIZOPHRENIA; SYMPTOMS; PSYCHOPATHOLOGY; CLOZAPINE; RECEPTORS;
D O I
10.1371/journal.pone.0257129
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background Antipsychotic agents are the basis for the pharmacological management of acute and chronic schizophrenia, bipolar disorders, mood disorders with psychotic feature, and other psychotic disorders. Antipsychotic medication use is frequently associated with unfavorable adverse effects such as extrapyramidal side effects (EPSEs). Hence, this systematic review and meta-analysis was aimed to determine the magnitude of antipsychotic-induced EPSEs. Method A literature search was conducted using legitimate databases, indexing services, and directories including PubMed/MEDLINE (Ovid(R)), EMBASE (Ovid(R)), google scholar and WorldCat to retrieve studies. Following screening and eligibility, the relevant data were extracted from the included studies using an Excel sheet and exported to STATA 15.0 software for analyses. The Random effects pooling model was used to analyze outcome measures at a 95% confidence interval. Besides, publication bias analysis was conducted. The protocol has been registered on PROSPERO with ID: CRD42020175168. Result In total, 15 original articles were included for the systematic review and meta-analysis. The pooled prevalence of antipsychotic-induced EPSEs among patient taking antipsychotic medications was 37% (95% CI: 18-55%, before sensitivity) and 31% (95% CI: 19-44%, after sensitivity). The prevalence of antipsychotic-induced parkinsonism, akathisia, and tardive dyskinesia was 20% (95% CI: 11-28%), 11% (95% CI: 6-17%), and 7% (95% CI: 4-9%), respectively. To confirm a small-study effect, Egger's regression test accompanied by funnel plot asymmetry demonstrated that there was a sort of publication bias in studies reporting akathisia and tardive dyskinesia. Conclusion The prevalence of antipsychotic-induced EPSEs was considerably high. One in five and more than one in ten patients experienced parkinsonism and akathisia, respectively. Appropriate prevention and early management of these effects can enhance the net benefits of antipsychotics.
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页数:17
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