Integrated microfluidic biochips for electrochemical detection of multiple bioagents

被引：0

作者：

Liu, RH ^{[1
]}

Ghindilis, A ^{[1
]}

Schwarzkopf, K ^{[1
]}

Strathmann, M ^{[1
]}

机构：

[1] Combimatrix Corp, Mukilteo, WA 98275 USA

来源：

Micro Total Analysis Systems 2004, Vol 2 | 2005年 / 297期

关键词：

electrochemical detection; microarray; DNA; antibody; antigen;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Microfluidic biochip devices have been developed to perform detection of multiple bioagents using electrochemical detection methods. Microfluidic mixer, pumps, channels, chambers, and Combimatrix microelectrode array are integrated to perform parallel immunoassays to detect infectious particles (viruses and bacteria) from complex biological samples in a single, fully automated biochip device. The same platform is also used for DNA analysis. The enzyme-based electrochemical detection has many advantages including high sensitivity (similar to fM) and simple apparatus.

引用

页码：578 / 580

页数：3

共 3 条

[1] Immunoassays and sequence-specific DNA detection on a microchip using enzyme amplified electrochemical detection
Dill, K
Montgomery, DD
Ghindilis, AL
Schwarzkopf, KR
[J]. JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS, 2004, 59 (02): : 181 - 187
[2] Antigen detection using microelectrode array microchips
Dill, K
Montgomery, DD
Wang, W
Tsai, JC
[J]. ANALYTICA CHIMICA ACTA, 2001, 444 (01) : 69 - 78
[3] Self-contained, fully integrated biochip for sample preparation, polymerase chain reaction amplification, and DNA microarray detection
Liu, RH
Yang, JN
Lenigk, R
Bonanno, J
Grodzinski, P
[J]. ANALYTICAL CHEMISTRY, 2004, 76 (07) : 1824 - 1831

← 1 →