The Rakicidin Family of Anticancer Natural Products - Synthetic Strategies towards a New Class of Hypoxia-Selective Cytotoxins

被引：19

作者：

Tsakos, Michail ^{[1
,2
]}

Jacobsen, Kristian M. ^{[1
]}

Yu, Wanwan ^{[1
]}

Villadsen, Nikolaj L. ^{[1
]}

Poulsen, Thomas B. ^{[1
]}

机构：

[1] Aarhus Univ, Dept Chem, Langelandsgade 140, DK-8000 Aarhus C, Denmark

[2] McGill Univ, Dept Chem, 801 Sherbrooke St West,Room 300, Montreal, PQ H3A 0B8, Canada

来源：

SYNLETT | 2016年 / 27卷 / 13期

关键词：

total synthesis; cyclic peptide; cancer; tumor hypoxia; natural products; CANCER STEM-CELLS; STREPTOMYCES SP; ABSOLUTE-CONFIGURATION; MICROMONOSPORA SP; DRUG DISCOVERY; VINYLAMYCIN; DEPSIPEPTIDE; ROUTE;

D O I：

10.1055/s-0035-1561465

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Rakicidin A is a prominent member of a small class of macrocyclic lipodepsipeptide natural products that contain an electrophilic 4-amido-2,4-pentadienoate (APD) functionality. Rakicidin A displays selective growth inhibitory activity against hypoxic cancer cells as well as imatinib-resistant chronic myelogenous leukemia (CML) cells. In this paper we present and discuss the two known synthetic routes to rakicidin A, which provide an instructive comparison of strategies used to address the synthetic challenges inherent to rakicidin A. In addition to the synthetic discussion we provide a status on the ongoing biological investigations and emerging structure-activity relationships of the rakicidin scaffold. 1 Introduction 2 The APD-CLD Class of Natural Products 3 Total Syntheses of Rakicidin A 4 Biological Investigations of Rakicidin A and Analogues 5 Conclusion and Perspectives

引用

页码：1898 / 1906

页数：9

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