Special Considerations for Supportive Care and Management of Complications in Elderly Patients With Multiple Myeloma

被引：6

作者：

George, Laeth L. ^{[1
]}

Malik, Mustafa N. ^{[2
]}

Miller, Eric J. ^{[3
]}

Hicks, Kayla ^{[4
]}

Khanam, Razwana ^{[5
]}

Saterehaseman, Alireza ^{[6
]}

McNichol, Megan ^{[7
]}

Anwer, Faiz ^{[8
]}

机构：

[1] Univ Hosp Cleveland, Med Ctr, Dept Internal Med, Cleveland, OH 44106 USA

[2] Univ Arizona, Dept Internal Med, Tucson, AZ USA

[3] Beth Israel Deaconess Med Ctr, Dept Internal Med, Boston, MA 02215 USA

[4] Case Western Reserve Univ, Sch Med, Hlth Educ Campus, Cleveland, OH 44106 USA

[5] Univ Pittsburgh, Med Ctr McKeesport, Dept Internal Med, Mckeesport, PA USA

[6] Cleveland Clin, Taussig Canc Ctr, Cleveland, OH 44106 USA

[7] Beth Israel Deaconess Med Ctr, Knowledge Serv, Boston, MA 02215 USA

[8] Cleveland Clin, Div Hematol & Oncol, Cleveland, OH 44106 USA

来源：

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA | 2021年 / 21卷 / 12期

关键词：

Anemia; Bone; Frail; Infection; Renal Failure; Thromboembolism; PNEUMOCOCCAL POLYSACCHARIDE VACCINE; STEM-CELL TRANSPLANTATION; ZOLEDRONIC ACID; DOUBLE-BLIND; ADVISORY-COMMITTEE; RANDOMIZED-TRIAL; OLDER-ADULTS; IMMUNIZATION PRACTICES; RENAL-FAILURE; CONJUGATE VACCINE;

D O I：

10.1016/j.clml.2021.07.013

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Multiple myeloma is a progressive and incurable hematologic malignancy. It is predominantly a disease of older individuals, with a third of these patients considered to be elderly. In recent years, there has been a focus and emphasis on identifying and stratifying patients based on their functional status and frailty. There are several hallmark complications of the disease-hypercalcemia, renal insufficiency, anemia, bone pain-along with thromboembolism and compromised immunity that are common in patients with multiple myeloma. Due to the wide range of patient ages and functional status, there are, accordingly, different considerations for management of the above complications based on numerous factors, including frailty status. This review focuses on considerations and management of common complications of multiple myeloma in elderly patients. These include renal failure, skeletal complications, anemia, thromboembolism, and infectious complications. (C) 2021 Elsevier Inc. All rights reserved.

引用

页码：812 / 822

页数：11

共 115 条

[1] Frailty: An emerging Geriatric syndrome [J].

Ahmed, Nasiya ;

Mandel, Richard ;

Fain, Mindy J. .

AMERICAN JOURNAL OF MEDICINE, 2007, 120 (09) :748-753

[2]

Altekruse S.F., 2009, SEER Cancer Statistics Review, 1975-2007

[3] Lenalidomide Maintenance after Stem-Cell Transplantation for Multiple Myeloma [J].

Attal, Michel ;

Lauwers-Cances, Valerie ;

Marit, Gerald ;

Caillot, Denis ;

Moreau, Philippe ;

Facon, Thierry ;

Stoppa, Anne Marie ;

Hulin, Cyrille ;

Benboubker, Lofti ;

Garderet, Laurent ;

Decaux, Olivier ;

Leyvraz, Serge ;

Vekemans, Marie-Christiane ;

Voillat, Laurent ;

Michallet, Mauricette ;

Pegourie, Brigitte ;

Dumontet, Charles ;

Roussel, Murielle ;

Leleu, Xavier ;

Mathiot, Claire ;

Payen, Catherine ;

Avet-Loiseau, Herve ;

Harousseau, Jean-Luc .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (19) :1782-1791

[4] High-dose chemotherapy and autologous peripheral blood stem cell transplantation in patients with multiple myeloma and renal insufficiency [J].

Ballester, OF ;

Tummala, R ;

Janssen, WE ;

Fields, KK ;

Hiemenz, JW ;

Goldstein, SC ;

Perkins, JB ;

Sullivan, DM ;

Rosen, R ;

Sackstein, R ;

Zorsky, P ;

Saez, R ;

Elfenbein, GJ .

BONE MARROW TRANSPLANTATION, 1997, 20 (08) :653-656

[5] Treatment of multiple myeloma [J].

Barlogie, B ;

Shaughnessy, J ;

Tricot, G ;

Jacobson, J ;

Zangari, M ;

Anaissie, E ;

Walker, R ;

Crowley, J .

BLOOD, 2004, 103 (01) :20-32

[6] Identification of Risk Factors for Bisphosphonate-Associated Atypical Femoral Fractures and Osteonecrosis of the Jaw in a Pharmacovigilance Database [J].

Bejhed, Rebecca S. ;

Kharazmi, Mohammad ;

Hallberg, Par .

ANNALS OF PHARMACOTHERAPY, 2016, 50 (08) :616-624

[7] The use of octagam and gammanorm in immunodeficiency associated with hematological malignancies: a prospective study from 21 French hematology departments [J].

Benbrahim, Omar ;

Viallard, Jean-Francois ;

Choquet, Sylvain ;

Royer, Bruno ;

Bauduer, Frederic ;

Decaux, Olivier ;

Crave, Jean-Charles ;

Fardini, Yann ;

Clerson, Pierre ;

Levy, Vincent .

HEMATOLOGY, 2019, 24 (01) :173-182

[8] Use of 13-Valent Pneumococcal Conjugate Vaccine and 23-Valent Pneumococcal Polysaccharide Vaccine for Adults With Immunocompromising Conditions: Recommendations of the Advisory Committee on Immunization Practices (ACIP) [J].

Bennett, Nancy M. ;

Whitney, Cynthia G. ;

Moore, Matt ;

Pilishvili, Tamara ;

Dooling, Kathleen L. .

AMERICAN JOURNAL OF TRANSPLANTATION, 2013, 13 (01) :232-235

[9] Pharmacokinetics and Safety of Elotuzumab Combined With Lenalidomide and Dexamethasone in Patients With Multiple Myeloma and Various Levels of Renal Impairment: Results of a Phase Ib Study [J].

Berdeja, Jesus ;

Jagannath, Sunday ;

Zonder, Jeffrey ;

Badros, Ashraf ;

Kaufman, Jonathan L. ;

Manges, Robert ;

Gupta, Manish ;

Tendolkar, Amol ;

Lynch, Mark ;

Bleickardt, Eric ;

Paliwal, Prashni ;

Vij, Ravi .

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2016, 16 (03) :129-138

[10]

Berenson JR, 2001, CANCER, V91, P1191, DOI 10.1002/1097-0142(20010401)91:7<1191::AID-CNCR1119>3.0.CO

← 1 2 3 4 5 6 7 8 9 10 →