Breast Cancer Stem Cells

被引：59

作者：

Crabtree, Judy S.

Miele, Lucio ^{[1
]}

机构：

[1] Louisiana State Univ, Hlth Sci Ctr, Dept Genet, New Orleans, LA 70112 USA

来源：

BIOMEDICINES | 2018年 / 6卷 / 03期

基金：

美国国家卫生研究院;

关键词：

breast cancer; stem cells; Notch; Wnt; Hedgehog; Hippo; HEDGEHOG SIGNALING PATHWAY; MAMMARY EPITHELIAL-CELLS; MCF-7 MAMMOSPHERE CELLS; ACUTE MYELOID-LEUKEMIA; HIPPO TRANSDUCER TAZ; IN-VITRO PROPAGATION; ALDEHYDE DEHYDROGENASE; DOWN-REGULATION; TARGETING NOTCH; SELF-RENEWAL;

D O I：

10.3390/biomedicines6030077

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Breast cancer stem cells (BCSC) have been implicated in tumor initiation, progression, metastasis, recurrence, and resistance to therapy. The origins of BCSCs remain controversial due to tumor heterogeneity and the presence of such small side populations for study, but nonetheless, cell surface markers and their correlation with BCSC functionality continue to be identified. BCSCs are driven by persistent activation of developmental pathways, such as Notch, Wnt, Hippo, and Hedgehog and new treatment strategies that are aimed at these pathways are in preclinical and clinical development.

引用

页数：14

共 132 条

[21] ER-α36-Mediated Rapid Estrogen Signaling Positively Regulates ER-Positive Breast Cancer Stem/Progenitor Cells [J].

Deng, Hao ;

Zhang, Xin-Tian ;

Wang, Mo-Lin ;

Zheng, Hong-Yan ;

Liu, Li-Jiang ;

Wang, Zhao-Yi .

PLOS ONE, 2014, 9 (02)

[22] Secreted Frizzled-related protein 4 (sFRP4) chemo-sensitizes cancer stem cells derived from human breast, prostate, and ovary tumor cell lines [J].

Deshmukh, A. ;

Kumar, S. ;

Arfuso, F. ;

Newsholme, P. ;

Dharmarajan, A. .

SCIENTIFIC REPORTS, 2017, 7

[23] Role of epigenetic modulation in cancer stem cell fate [J].

Deshmukh, Abhijeet ;

Binju, Mudra ;

Arfuso, Frank ;

Newsholme, Philip ;

Dharmarajan, Arun .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2017, 90 :9-16

[24] Wnt signaling in triple negative breast cancer is associated with metastasis [J].

Dey, Nandini ;

Barwick, Benjamin G. ;

Moreno, Carlos S. ;

Ordanic-Kodani, Maja ;

Chen, Zhengjia ;

Oprea-Ilies, Gabriella ;

Tang, Weining ;

Catzavelos, Charles ;

Kerstann, Kimberly F. ;

Sledge, George W., Jr. ;

Abramovitz, Mark ;

Bouzyk, Mark ;

De, Pradip ;

Leyland-Jones, Brian R. .

BMC CANCER, 2013, 13

[25] Nuclear TAZ expression associates with the triple-negative phenotype in breast cancer [J].

Diaz-Martin, Juan ;

Angeles Lopez-Garcia, Maria ;

Romero-Perez, Laura ;

Reina Atienza-Amores, Maria ;

Luisa Pecero, Maria ;

Angeles Castilla, Maria ;

Biscuola, Michele ;

Santon, Almudena ;

Palacios, Jose .

[26] Stem cells in normal breast development and breast cancer [J].

Dontu, G ;

Al-Hajj, M ;

Abdallah, WA ;

Clarke, MF ;

Wicha, MS .

CELL PROLIFERATION, 2003, 36 :59-72

[27] Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells [J].

Dontu, G ;

Jackson, KW ;

McNicholas, E ;

Kawamura, MJ ;

Abdallah, WM ;

Wicha, MS .

BREAST CANCER RESEARCH, 2004, 6 (06) :R605-R615

[28] Breast cancer, stem/progenitor cells and the estrogen receptor [J].

Dontu, G ;

El-Ashry, D ;

Wicha, MS .

TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2004, 15 (05) :193-197

[29] In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells [J].

Dontu, G ;

Abdallah, WM ;

Foley, JM ;

Jackson, KW ;

Clarke, MF ;

Kawamura, MJ ;

Wicha, MS .

GENES & DEVELOPMENT, 2003, 17 (10) :1253-1270

[30] Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution [J].

Eirew, Peter ;

Steif, Adi ;

Khattra, Jaswinder ;

Ha, Gavin ;

Yap, Damian ;

Farahani, Hossein ;

Gelmon, Karen ;

Chia, Stephen ;

Mar, Colin ;

Wan, Adrian ;

Laks, Emma ;

Biele, Justina ;

Shumansky, Karey ;

Rosner, Jamie ;

McPherson, Andrew ;

Nielsen, Cydney ;

Roth, Andrew J. L. ;

Lefebvre, Calvin ;

Bashashati, Ali ;

de Souza, Camila ;

Siu, Celia ;

Aniba, Radhouane ;

Brimhall, Jazmine ;

Oloumi, Arusha ;

Osako, Tomo ;

Bruna, Alejandra ;

Sandoval, Jose L. ;

Algara, Teresa ;

Greenwood, Wendy ;

Leung, Kaston ;

Cheng, Hongwei ;

Xue, Hui ;

Wang, Yuzhuo ;

Lin, Dong ;

Mungall, Andrew J. ;

Moore, Richard ;

Zhao, Yongjun ;

Lorette, Julie ;

Long Nguyen ;

Huntsman, David ;

Eaves, Connie J. ;

Hansen, Carl ;

Marra, Marco A. ;

Caldas, Carlos ;

Shah, Sohrab P. ;

Aparicio, Samuel .

NATURE, 2015, 518 (7539) :422-426

← 1 2 3 4 5 6 7 8 9 10 →