Breast Cancer Stem Cells

被引：59
作者：
Crabtree, Judy S.
Miele, Lucio [1 ]
机构：
[1] Louisiana State Univ, Hlth Sci Ctr, Dept Genet, New Orleans, LA 70112 USA
来源：
BIOMEDICINES | 2018年 / 6卷 / 03期
基金：
美国国家卫生研究院;
关键词：
breast cancer; stem cells; Notch; Wnt; Hedgehog; Hippo; HEDGEHOG SIGNALING PATHWAY; MAMMARY EPITHELIAL-CELLS; MCF-7 MAMMOSPHERE CELLS; ACUTE MYELOID-LEUKEMIA; HIPPO TRANSDUCER TAZ; IN-VITRO PROPAGATION; ALDEHYDE DEHYDROGENASE; DOWN-REGULATION; TARGETING NOTCH; SELF-RENEWAL;
D O I：
10.3390/biomedicines6030077
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Breast cancer stem cells (BCSC) have been implicated in tumor initiation, progression, metastasis, recurrence, and resistance to therapy. The origins of BCSCs remain controversial due to tumor heterogeneity and the presence of such small side populations for study, but nonetheless, cell surface markers and their correlation with BCSC functionality continue to be identified. BCSCs are driven by persistent activation of developmental pathways, such as Notch, Wnt, Hippo, and Hedgehog and new treatment strategies that are aimed at these pathways are in preclinical and clinical development.
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页数：14
相关论文
共 132 条
[1]   Stem cells in breast tumours: Are they ready for the clinic? [J].
Ablett, Matthew P. ;
Singh, Jagdeep K. ;
Clarke, Robert B. .
EUROPEAN JOURNAL OF CANCER, 2012, 48 (14) :2104-2116
[2]   Prospective identification of tumorigenic breast cancer cells [J].
Al-Hajj, M ;
Wicha, MS ;
Benito-Hernandez, A ;
Morrison, SJ ;
Clarke, MF .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (07) :3983-3988
[3]   The Role of Steroid Hormones in Breast and Effects on Cancer Stem Cells [J].
Alferez D.G. ;
Simões B.M. ;
Howell S.J. ;
Clarke R.B. .
Current Stem Cell Reports, 2018, 4 (1) :81-94
[4]  
[Anonymous], ONCOGENE
[5]  
[Anonymous], SURV EP END RESEER
[6]  
[Anonymous], 2017, STEM CELLS INT
[7]   Control of mammary stem cell function by steroid hormone signalling [J].
Asselin-Labat, Marie-Liesse ;
Vaillant, Francois ;
Sheridan, Julie M. ;
Pal, Bhupinder ;
Wu, Di ;
Simpson, Evan R. ;
Yasuda, Hisataka ;
Smyth, Gordon K. ;
Martin, T. John ;
Lindeman, Geoffrey J. ;
Visvader, Jane E. .
NATURE, 2010, 465 (7299) :798-802
[8]   Hypoxia inducible factor-1 is activated by transcriptional co-activator with PDZ-binding motif (TAZ) versus WWdomain-containing oxidoreductase (WWOX) in hypoxic microenvironment of bone metastasis from breast cancer [J].
Bendinelli, Paola ;
Maroni, Paola ;
Matteucci, Emanuela ;
Luzzati, Alessandro ;
Perrucchini, Giuseppe ;
Desiderio, Maria Alfonsina .
EUROPEAN JOURNAL OF CANCER, 2013, 49 (11) :2608-2618
[9]   CD24-/low stem-like breast cancer marker defines the radiation-resistant cells involved in memorization and transmission of radiation-induced genomic instability [J].
Bensimon, J. ;
Altmeyer-Morel, S. ;
Benjelloun, H. ;
Chevillard, S. ;
Lebeau, J. .
ONCOGENE, 2013, 32 (02) :251-258
[10]   Treatment of Triple-Negative Breast Cancer with TORC1/2 Inhibitors Sustains a Drug-Resistant and Notch-Dependent Cancer Stem Cell Population [J].
Bhola, Neil E. ;
Jansen, Valerie M. ;
Koch, James P. ;
Li, Hua ;
Formisano, Luigi ;
Williams, Janice A. ;
Grandis, Jennifer R. ;
Arteaga, Carlos L. .
CANCER RESEARCH, 2016, 76 (02) :440-452
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