Association between Angiopoietin-2 Gene Polymorphisms and Susceptibility to Coronary Artery Disease

被引：2

作者：

Lan, Luhang ^{[1
]}

Kang, Le ^{[2
]}

Lu, Liang ^{[1
]}

Ge, Xuan ^{[1
]}

Si, Hongping ^{[1
]}

Peng, Jiren ^{[1
]}

Wang, Maofeng ^{[2
]}

Li, Weimin ^{[1
]}

Su, Chen-Ming ^{[3
]}

机构：

[1] Wenzhou Med Univ, Affiliated Dongyang Hosp, Dept Cardiol, Wuningxi Rd 60, Dongyang, Zhejiang, Peoples R China

[2] Wenzhou Med Univ, Dept Biomed Sci Lab, Affiliated Dongyang Hosp, Wuningxi Rd 60, Dongyang, Zhejiang, Peoples R China

[3] China Med Univ, Dept Sports Med, 91 Hsueh Shih Rd, Taichung, Taiwan

来源：

ARCHIVES OF IRANIAN MEDICINE | 2021年 / 24卷 / 08期

关键词：

Angiopoietin-2; Coronary artery disease; Single nucleotide polymorphism; THERAPEUTIC ANGIOGENESIS; GLOBAL BURDEN; FIBRINOLYSIS; HAPLOTYPE; TIE-2; RISK;

D O I：

10.34172/aim.2021.88

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Angiopoietin-2 (Angpt2) is associated with the progression of coronary artery disease (CAD). This research aimed to investigate the possible association between single nucleotide polymorphisms (SNPs) of ANGPT2 and CAD. Methods: This research was performed in a hospital from the eastern region of China. From February 2019 to June 2019, 222 patients with CAD were newly diagnosed and 403 healthy controls were confirmed by physical examinations. The distribution frequency of five SNPs of the ANGPT2 (rs11137037, rs2442598, rs12674822, rs1823375, and rs734701) in all participants was analyzed by real-time polymerase chain reaction (PCR) with SNP locus-specific probes. Results: Our data showed that the participants with the TT genotype of rs2442598 were at reduced risk of CAD compared with wild-types (adjusted odds ratio [AOR] = 0.511, 95% CI: 0.283-0.923). The participants with the AC and AC+CC genotypes of rs11137037 were at greater risk of CAD compared to wild-types (AOR = 1.754, 95% CI: 1.140-2.699; AOR = 1.731, 95% CI: 1.165-2.573, respectively). In addition, carriers of the GG+TT genotypes of rs12674822, showed more significant high-density lipoprotein than those of GG genotype, in addition, carriers of the GG+TT genotypes of rs12674822, showed more significant high-density lipoprotein than those of GG genotype (P=0.037). Conclusion: These findings, as well as analysis of the haplotype, clearly indicate that ANGPT2 SNPs were highly correlated with to CAD the Han Chinese

引用

页码：622 / 628

页数：7

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