Marimastat alleviates oxidative stress induced cellular senescence by activating autophagy

被引：3

作者：

Xia, Jing ^{[1
,2
]}

Chen, Jun ^{[3
]}

Vashisth, Manoj Kumar ^{[1
,2
]}

Jia, Huijie ^{[1
,2
]}

Hua, Hui ^{[1
,2
]}

Wu, Xiao-jian ^{[4
]}

Wang, Xiao-bo ^{[1
,2
,5
]}

机构：

[1] Dali Univ, Sch Basic Med, Dali 671000, Yunnan, Peoples R China

[2] Key Lab Univ Cell Biol Yunnan Prov, Dali 671000, Yunnan, Peoples R China

[3] Chinese Med Hosp Shizhong, Dept Foot & Ankle Surg, Dist Leshan 12511002451599964Y, Leshan 614000, Sichuan, Peoples R China

[4] Guangxi Acad Agr Sci, Microbiol Res Inst, Nanning 530007, Guangxi, Peoples R China

[5] Dali Univ, Sch Basic Med, Dept Human Anat omy Histol & Embryol, Dali 671000, Yunnan, Peoples R China

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2022年 / 620卷

基金：

中国国家自然科学基金;

关键词：

Marimastat; Senescence; Oxidative stress; Autophagy; mTOR;

D O I：

10.1016/j.bbrc.2022.06.075

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Marimastat is one of the potent inhibitors of MMP (MMPIs) with few side effects. The impact of marimastat on cellular senescence remains unexplored. Our study evaluated the marimastate effect on oxidative stress-induced cell senescence using NIH3T3 cells. Marimastate administration was found to suppress senescence-beta-galactosidase (SA-beta-gal) activity and development linked with aging. Further-more, we observed that this effect of marimastat was closely linked with the recovery of autophagy dysfunction and mTOR suppression in H2O2-treated cells. Notably, this study demonstrated the mar-imastat effect on senescence inhibition for the first time. (C) 2022 Elsevier Inc. All rights reserved.

引用

页码：121 / 128

页数：8

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