NMR spectroscopy of lipidic cubic phases

被引：8
作者：
Rajput, Sunnia [1 ]
Yao, Shenggen [1 ]
Keizer, David W. [1 ]
Sani, Marc-Antoine [1 ,2 ]
Separovic, Frances [1 ,2 ]
机构：
[1] Univ Melbourne, Bio21 Mol Sci & Biotechnol Inst, Parkville, Vic 3052, Australia
[2] Univ Melbourne, Sch Chem, Melbourne, Vic 3010, Australia
来源：
BIOPHYSICAL REVIEWS | 2022年 / 14卷 / 01期
关键词：
Cubic phase; Encapsulation; Membrane protein; NMR; Pulsed field gradient; Diffusion; NUCLEAR-MAGNETIC-RESONANCE; TRANSLATIONAL DIFFUSION-COEFFICIENTS; CONTROLLING RELEASE; MEMBRANE; PROTEINS; PEPTIDES; DYNAMICS; RELAXATION; CUBOSOMES; TRANSPORT;
D O I：
10.1007/s12551-021-00900-y
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
Lipidic cubic phase (LCP) structures have been used for stabilisation and crystallisation of membrane proteins and show promising properties as drug carriers. In this mini-review, we present how NMR spectroscopy has played a major role in understanding the physico-chemical properties of LCPs and how recent advances in pulsed field gradient NMR techniques open new perspectives in characterising encapsulated molecules.
引用
收藏
页码：67 / 74
页数：8
相关论文
共 78 条
[51]   WATCHING FAT DIGESTION [J].
PATTON, JS ;
CAREY, MC .
SCIENCE, 1979, 204 (4389) :145-148
[52]   Evaluating the link between self-assembled mesophase structure and drug release [J].
Phan, Stephanie ;
Fong, Wye-Khay ;
Kirby, Nigel ;
Hanley, Tracey ;
Boyd, Ben J. .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2011, 421 (01) :176-182
[53]   THEORY OF HYDROPHOBIC EFFECTS [J].
PRATT, LR .
ANNUAL REVIEW OF PHYSICAL CHEMISTRY, 1985, 36 :433-449
[54]  
Price W. S., 2009, NMR Studies of Translational Motion: Principles and Applications
[55]  
Priestley E.B., 1976, Introduction to Liquid Crystals
[56]   Solution NMR: A powerful tool for structural and functional studies of membrane proteins in reconstituted environments [J].
Puthenveetil, Robbins ;
Vinogradova, Olga .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2019, 294 (44) :15914-15931
[57]   The Druggable Genome: Evaluation of Drug Targets in Clinical Trials Suggests Major Shifts in Molecular Class and Indication [J].
Rask-Andersen, Mathias ;
Masuram, Surendar ;
Schioth, Helgi B. .
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 54, 2014, 54 :9-26
[58]   Bicontinuous cubic liquid crystals as sustained delivery systems for peptides and proteins [J].
Rizwan, Shakila B. ;
Boyd, Ben J. ;
Rades, Thomas ;
Hook, Sarah .
EXPERT OPINION ON DRUG DELIVERY, 2010, 7 (10) :1133-1144
[59]  
Sani MA, 2014, NEW DEV NMR, V3, P287
[60]   The lipid network [J].
Marc-Antoine Sani ;
Frances Separovic ;
John D. Gehman .
Biophysical Reviews, 2012, 4 (4) :283-290
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