NMR spectroscopy of lipidic cubic phases

被引：8

作者：

Rajput, Sunnia ^{[1
]}

Yao, Shenggen ^{[1
]}

Keizer, David W. ^{[1
]}

Sani, Marc-Antoine ^{[1
,2
]}

Separovic, Frances ^{[1
,2
]}

机构：

[1] Univ Melbourne, Bio21 Mol Sci & Biotechnol Inst, Parkville, Vic 3052, Australia

[2] Univ Melbourne, Sch Chem, Melbourne, Vic 3010, Australia

来源：

BIOPHYSICAL REVIEWS | 2022年 / 14卷 / 01期

关键词：

Cubic phase; Encapsulation; Membrane protein; NMR; Pulsed field gradient; Diffusion; NUCLEAR-MAGNETIC-RESONANCE; TRANSLATIONAL DIFFUSION-COEFFICIENTS; CONTROLLING RELEASE; MEMBRANE; PROTEINS; PEPTIDES; DYNAMICS; RELAXATION; CUBOSOMES; TRANSPORT;

D O I：

10.1007/s12551-021-00900-y

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Lipidic cubic phase (LCP) structures have been used for stabilisation and crystallisation of membrane proteins and show promising properties as drug carriers. In this mini-review, we present how NMR spectroscopy has played a major role in understanding the physico-chemical properties of LCPs and how recent advances in pulsed field gradient NMR techniques open new perspectives in characterising encapsulated molecules.

引用

页码：67 / 74

页数：8

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