Thermo-sensitive poly(VCL-4VP-NVP) ionic microgels: synthesis, cytotoxicity, hemocompatibility, and sustained release of anti-inflammatory drugs

被引：10

作者：

Zhou, Xianjing ^{[1
]}

Yang, Qing ^{[1
]}

Li, Jianyuan ^{[1
]}

Nie, Jingjing ^{[2
]}

Tang, Guping ^{[2
]}

Du, Binyang ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Polymer Sci & Engn, MOE Key Lab Macromol Synth & Functionalizat, Hangzhou 310027, Peoples R China

[2] Zhejiang Univ, Dept Chem, Hangzhou 310027, Peoples R China

来源：

MATERIALS CHEMISTRY FRONTIERS | 2017年 / 1卷 / 02期

基金：

中国国家自然科学基金;

关键词：

VINYLCAPROLACTAM-BASED MICROGELS; QUATERNIZATION CROSS-LINKING; IN-VITRO; BIOMEDICAL APPLICATIONS; RESPONSIVE MICROGELS; SALICYLIC-ACID; PH; DELIVERY; NANOPARTICLES; TEMPERATURE;

D O I：

10.1039/c6qm00046k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Thermosensitive poly(VCL-4VP-NVP) ionic microgels were prepared by in situ quaternization crosslinking reaction during surfactant free emulsion polymerization (SFEP) with N-vinylcaprolactam (VCL) as the main monomer, 4-vinylpyridine (4VP) as the quaternizable co-monomer, N-vinyl-2-pyrrolidone (NVP) as the second co-monomer and 1,6-dibromohexane (6Br) as the quaternization crosslinker. The obtained ionic microgels were spherical in shape with a narrow size distribution and exhibited thermo-sensitive behavior. These ionic microgels showed low cytotoxicity at concentrations lower than 25 mg mL(-1), excellent hemocompatibility at concentrations up to 1000 mg mL(-1), and could be up taken into the cytoplasm regime of HEK-293 cells without entering the nucleus. It was found that these ionic microgels were suitable for the loading and sustained release of a nonsteroidal anti-inflammatory drug, diclofenac sodium (DS). The drug loading content (DLC) of DS in the microgels could reach ca. 12% with an encapsulation efficiency (EE) of up to 68%. Furthermore, 60% loaded DS could be sustainably released at 37 degrees C from the drug-loaded microgels within 400 min following a first-order exponential kinetics.

引用

页码：369 / 379

页数：11