Synthesis, characterization, electrochemistry and evaluation of biological activities of some ferrocenyl Schiff bases

被引：52
作者：
Zaheer, Muhammad [1 ]
Shah, Afzal [1 ]
Akhter, Zareen [1 ]
Qureshi, Rumana [1 ]
Mirza, Bushra [2 ]
Tauseef, Misbah [2 ]
Bolte, Michael [3 ]
机构：
[1] Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan
[2] Quaid I Azam Univ, Dept Biochem, Islamabad 45320, Pakistan
[3] Goethe Univ Frankfurt, Inst Anorgan Chem, D-60438 Frankfurt, Germany
来源：
APPLIED ORGANOMETALLIC CHEMISTRY | 2011年 / 25卷 / 01期
关键词：
ferrocene; Schiff bases; electrochemistry; biological applications; DERIVATIVES; ABSORPTION; REDUCTION; CHEMISTRY; ANALOGS; COMPLEX; DNA;
D O I：
10.1002/aoc.1690
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Synthesis of ferrocenyl Schiff bases (1-6) was carried out by the condensation reaction of 4-ferrocenyl aniline with different substituted aromatic aldehydes and acetyl acetone. Compounds were characterized by physical measurements, elemental analysis, FT-IR, H-1-NMR and C-13-NMR spectroscopy. Single crystal X-ray analysis of compound 2 showed the co-planarity of both aromatic rings connected by a C-N double bond. Compounds demonstrated reversible one-electron redox behavior and their peak currents were found to increase linearly with the square root of the sweep rate nu(1/2). The overall electrode processes were found to be diffusion controlled. Compounds 1 and 4 showed low cytotoxicity and appreciable antifungal, antioxidant and DNA protection activities. Copyright (C) 2010 John Wiley & Sons, Ltd.
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收藏
页码：61 / 69
页数：9
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